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2016 ; 1
(4
): e000066
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English Wikipedia
The European Society for Medical Oncology Magnitude of Clinical Benefit Scale in
daily practice: a single institution, real-life experience at the Medical
University of Vienna
#MMPMID27843624
Kiesewetter B
; Raderer M
; Steger GG
; Bartsch R
; Pirker R
; Zöchbauer-Müller S
; Prager G
; Krainer M
; Preusser M
; Schmidinger M
; Zielinski CC
ESMO Open
2016[]; 1
(4
): e000066
PMID27843624
show ga
BACKGROUND: The European Society for Medical Oncology (ESMO) Magnitude of
Clinical Benefit Scale (MCBS) has been designed to stratify the therapeutic
benefit of a certain drug registered for the treatment of cancer. However, though
internally validated, this tool has not yet been evaluated for its feasibility in
the daily practice of a major center of medical oncology. METHODS: The
practicability of the MCBS for advanced oncological diseases at the Clinical
Division of Oncology, Medical University of Vienna, which constitutes one of the
largest oncological centres in Europe, was analysed in a three-step approach.
First, retrospectively collected data were analysed to gain an overview of
treatments in regular use. Second, data were scored by using the MCBS. Third, the
ensuing results were evaluated within corresponding programme directorships to
assess feasibility in a real-life clinical context. RESULTS: In the majority of
tumour entities, the MCBS results reported earlier are consistent with daily
clinical practice. Thus, in metastatic breast cancer or advanced lung cancer,
there was a high level of clinical benefit for first-line treatment standards,
and these results reflected well real-life experience. However, analyses based on
the first version of the MCBS are limited if it comes to salvage treatment in
tumour entities in which optimal sequencing of potential treatment options is of
major importance, as in metastatic colorectal or renal cell cancer. In contrast
to this, it is remarkable that certain novel therapies such as nivolumab assessed
for heavily pretreated advanced renal cancer reached the highest level of
clinical benefit due to prolongation in survival and a favourable toxicity
profile. The MCBS clearly underlines the potential benefit of these compounds.
CONCLUSIONS: The MCBS is an excellent tool for daily clinical practice of a
tertiary referral centre. It supports treatment decisions based on the clinical
benefit to be expected from a novel approach such as immunotherapy in as yet
untested indications.
free
free
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