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Advances in biodegradable nanomaterials for photothermal therapy of cancer #MMPMID27807498
He CF; Wang SH; Yu YJ; Shen HY; Zhao Y; Gao HL; Wang H; Li LL; Liu HY
Cancer Biol Med 2016[Sep]; 13 (3): 299-312 PMID27807498show ga
Photothermal cancer therapy is an alternative to chemotherapy, radiotherapy, and surgery. With the development of nanophotothermal agents, this therapy holds immense potential in clinical translation. However, the toxicity issues derived from the fact that nanomaterials are trapped and retained in the reticuloendothelial systems limit their biomedical application. Developing biodegradable photothermal agents is the most practical route to address these concerns. In addition to the physicochemical properties of nanomaterials, various internal and external stimuli play key roles on nanomaterials uptake, transport, and clearance. In this review, we summarized novel nanoplatforms for photothermal therapy; these nanoplatforms can elicit stimuli-triggered degradation. We focused on the recent innovative designs endowed with biodegradable photothermal agents under different stimuli, including enzyme, pH, and near-infrared (NIR) laser.