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10.1073/pnas.1613121113 http://scihub22266oqcxt.onion/10.1073/pnas.1613121113 C5068257!5068257!27671657     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (41): 11525-30 Nephropedia Template TP {{tp|p=27671657|t=2016. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis |pdf=|usr=}}{{27671657}} gab.com Text Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27671657 #FOAvip Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) are emerging as key regulators of cell fate in response to biochemical and biophysical cues, but their role in modulating vascular homeostasis in health and disease is not clearly understood. In studying the flow regulation of YAP/TAZ activities in vascular endothelial cells, we find that disturbed flow (without a clear direction), but not laminar flow (with a clear direction), activates YAP/TAZ to promote the atheroprone phenotypes (proliferation and inflammation). We also demonstrate that inhibition of YAP/TAZ attenuates the atheroprone phenotypes and lesion progression in atherosclerotic mice. These findings indicate that YAP/TAZ serve as important mechanotransducers in the disturbed flow-induced atherogenesis and provide insights to the development of therapeutic strategy for cardiovascular diseases. Twit Text FOAVip Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27671657 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27671657 #FOAvip English Wikipedia <ref>{{Cite pmid|27671657}}</ref> Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis #MMPMID27671657 Wang KC; Yeh YT; Nguyen P; Limqueco E; Lopez J; Thorossian S; Guan KL; Li YSJ; Chien S Proc Natl Acad Sci U S A 2016[Oct]; 113 (41): 11525-30 PMID27671657show ga Yes-associated protein (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) are emerging as key regulators of cell fate in response to biochemical and biophysical cues, but their role in modulating vascular homeostasis in health and disease is not clearly understood. In studying the flow regulation of YAP/TAZ activities in vascular endothelial cells, we find that disturbed flow (without a clear direction), but not laminar flow (with a clear direction), activates YAP/TAZ to promote the atheroprone phenotypes (proliferation and inflammation). We also demonstrate that inhibition of YAP/TAZ attenuates the atheroprone phenotypes and lesion progression in atherosclerotic mice. These findings indicate that YAP/TAZ serve as important mechanotransducers in the disturbed flow-induced atherogenesis and provide insights to the development of therapeutic strategy for cardiovascular diseases. äFlow-dependent YAP/TAZ activities regulate endothelial phenotypes and (epmc).pdf DeepDyve Pubget Overpricing