UNG protects B cells from AID-induced telomere loss #MMPMID27697833
Cortizas EM; Zahn A; Safavi S; Reed JA; Vega F; Di Noia JM; Verdun RE
J Exp Med 2016[Oct]; 213 (11): 2459-72 PMID27697833show ga
Verdun and colleagues find that the uracil-DNA glycosylase UNG, which promotes DNA breaks in the immunoglobulin genes during class switch recombination and is required for AID-induced chromosomal translocations, protects telomeres from AID-induced DNA damage and subsequent dysfunction.