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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Exp+Med 2016 ; 213 (11): 2437-57 Nephropedia Template TP
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The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells #MMPMID27647348
Roncagalli R; Cucchetti M; Jarmuzynski N; Grégoire C; Bergot E; Audebert S; Baudelet E; Menoita MG; Joachim A; Durand S; Suchanek M; Fiore F; Zhang L; Liang Y; Camoin L; Malissen M; Malissen B
J Exp Med 2016[Oct]; 213 (11): 2437-57 PMID27647348show ga
In two complementary papers, Casanova, Malissen, and collaborators report the discovery of human RLTPR deficiency, the first primary immunodeficiency of the human CD28 pathway in T cells. Together, the two studies elucidate the largely (but not completely) overlapping roles of RLTPR in CD28 signaling in T and B cells of humans and mice.