Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1084/jem.20160579 http://scihub22266oqcxt.onion/10.1084/jem.20160579 C5068240!5068240 !27647348     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27647348 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27647348 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2016 ; 213 (11 ): 2437-2457 Nephropedia Template TP {{tp|p=27647348 |t=2016. The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells |pdf=|usr=}}{{27647348 }} gab.com Text The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27647348 #FOAvip The RLTPR cytosolic protein, also known as CARMIL2, is essential for CD28 co-stimulation in mice, but its importance in human T cells and mode of action remain elusive. Here, using affinity purification followed by mass spectrometry analysis, we showed that RLTPR acts as a scaffold, bridging CD28 to the CARD11/CARMA1 cytosolic adaptor and to the NF-?B signaling pathway, and identified proteins not found before within the CD28 signaling pathway. We further demonstrated that RLTPR is essential for CD28 co-stimulation in human T cells and that its noncanonical pleckstrin-homology domain, leucine-rich repeat domain, and proline-rich region were mandatory for that task. Although RLTPR is thought to function as an actin-uncapping protein, this property was dispensable for CD28 co-stimulation in both mouse and human. Our findings suggest that the scaffolding role of RLTPR predominates during CD28 co-stimulation and underpins the similar function of RLTPR in human and mouse T cells. Along that line, the lack of functional RLTPR molecules impeded the differentiation toward Th1 and Th17 fates of both human and mouse CD4(+) T cells. RLTPR was also expressed in both human and mouse B cells. In the mouse, RLTPR did not play, however, any detectable role in BCR-mediated signaling and T cell-independent B cell responses. Twit Text FOAVip The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27647348 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27647348 #FOAvip English Wikipedia <ref>{{Cite pmid|27647348 }}</ref> The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells #MMPMID27647348 Roncagalli R ; Cucchetti M ; Jarmuzynski N ; Grégoire C ; Bergot E ; Audebert S ; Baudelet E ; Menoita MG ; Joachim A ; Durand S ; Suchanek M ; Fiore F ; Zhang L ; Liang Y ; Camoin L ; Malissen M ; Malissen B J Exp Med 2016[Oct]; 213 (11 ): 2437-2457 PMID27647348 show ga The RLTPR cytosolic protein, also known as CARMIL2, is essential for CD28 co-stimulation in mice, but its importance in human T cells and mode of action remain elusive. Here, using affinity purification followed by mass spectrometry analysis, we showed that RLTPR acts as a scaffold, bridging CD28 to the CARD11/CARMA1 cytosolic adaptor and to the NF-?B signaling pathway, and identified proteins not found before within the CD28 signaling pathway. We further demonstrated that RLTPR is essential for CD28 co-stimulation in human T cells and that its noncanonical pleckstrin-homology domain, leucine-rich repeat domain, and proline-rich region were mandatory for that task. Although RLTPR is thought to function as an actin-uncapping protein, this property was dispensable for CD28 co-stimulation in both mouse and human. Our findings suggest that the scaffolding role of RLTPR predominates during CD28 co-stimulation and underpins the similar function of RLTPR in human and mouse T cells. Along that line, the lack of functional RLTPR molecules impeded the differentiation toward Th1 and Th17 fates of both human and mouse CD4(+) T cells. RLTPR was also expressed in both human and mouse B cells. In the mouse, RLTPR did not play, however, any detectable role in BCR-mediated signaling and T cell-independent B cell responses. |Amino Acid Motifs [MESH] |Animals [MESH] |CD28 Antigens/*metabolism [MESH] |Dendritic Cells/metabolism [MESH] |Endocytosis [MESH] |Gene Targeting [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Jurkat Cells [MESH] |Killer Cells, Natural/metabolism [MESH] |Lymphocytes/metabolism [MESH] |Mice [MESH] |Microfilament Proteins/chemistry/*metabolism [MESH] |Models, Biological [MESH] |Mutation/genetics [MESH] |Myeloid Cells/metabolism [MESH] |Protein Domains [MESH] |Protein Interaction Mapping [MESH] |Protein Multimerization [MESH] |Proteomics [MESH] |Signal Transduction [MESH] |T-Lymphocytes, Regulatory/metabolism [MESH] |T-Lymphocytes/*metabolism [MESH]The scaffolding function of the RLTPR protein explains its essential r(epmc).pdf DeepDyve Pubget Overpricing