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10.1084/jem.20160417 http://scihub22266oqcxt.onion/10.1084/jem.20160417 C5068236!5068236 !27670591     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27670591 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Exp+Med 2016 ; 213 (11 ): 2281-2291 Nephropedia Template TP {{tp|p=27670591 |t=2016. IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells |pdf=|usr=}}{{27670591 }} gab.com Text IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27670591 #FOAvip IL-6 is known to contribute to the differentiation of CD4(+) T cells into different subsets of effector T helper cells. Less is known about the potential of IL-6 in regulating CD8(+) T cell effector function. Here, we identify IL-6 as a master regulator of IL-21 in effector CD8(+) T cells. IL-6 promotes the differentiation of a subset of naive CD8(+) T cells that express IL-6R into a unique population of effector CD8(+) T cells characterized by the production of high levels of IL-21 and low levels of IFN-?. Similar to CD4(+) T follicular helper (Tfh) cells, IL-21-producing CD8(+) T cells generated in the presence of IL-6 directly provide help to B cells to induce isotype switching. CD8(+) T cell-derived IL-21 contributes to the production of protective virus-specific IgG antibodies during influenza virus infection. Thus, this study reveals the presence of a new mechanism by which IL-6 regulates antibody production during viral infection, and a novel function of effector CD8(+) T cells in the protection against viruses. Twit Text FOAVip IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=27670591 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27670591 #FOAvip English Wikipedia <ref>{{Cite pmid|27670591 }}</ref> IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells #MMPMID27670591 Yang R ; Masters AR ; Fortner KA ; Champagne DP ; Yanguas-Casás N ; Silberger DJ ; Weaver CT ; Haynes L ; Rincon M J Exp Med 2016[Oct]; 213 (11 ): 2281-2291 PMID27670591 show ga IL-6 is known to contribute to the differentiation of CD4(+) T cells into different subsets of effector T helper cells. Less is known about the potential of IL-6 in regulating CD8(+) T cell effector function. Here, we identify IL-6 as a master regulator of IL-21 in effector CD8(+) T cells. IL-6 promotes the differentiation of a subset of naive CD8(+) T cells that express IL-6R into a unique population of effector CD8(+) T cells characterized by the production of high levels of IL-21 and low levels of IFN-?. Similar to CD4(+) T follicular helper (Tfh) cells, IL-21-producing CD8(+) T cells generated in the presence of IL-6 directly provide help to B cells to induce isotype switching. CD8(+) T cell-derived IL-21 contributes to the production of protective virus-specific IgG antibodies during influenza virus infection. Thus, this study reveals the presence of a new mechanism by which IL-6 regulates antibody production during viral infection, and a novel function of effector CD8(+) T cells in the protection against viruses. |*Cell Differentiation [MESH] |Animals [MESH] |B-Lymphocytes/*immunology [MESH] |CD8-Positive T-Lymphocytes/*immunology [MESH] |Immunoglobulin Class Switching [MESH] |Immunoglobulin G/metabolism [MESH] |Interleukin-21 [MESH] |Interleukin-6/*metabolism [MESH] |Interleukins/*biosynthesis [MESH] |Lymphocyte Subsets/metabolism [MESH] |Mice, Knockout [MESH] |Orthomyxoviridae Infections/immunology/pathology [MESH]IL-6 promotes the differentiation of a subset of naive CD8+ T cells in(epmc).pdf DeepDyve Pubget Overpricing