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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Mol+Cell+Oncol 2016 ; 3 (5): ä Nephropedia Template TP
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A novel role for DNA single-strand breaks in senescence and neoplastic escape of epithelial cells #MMPMID27857969
Nassour J; Abbadie C
Mol Cell Oncol 2016[]; 3 (5): ä PMID27857969show ga
In contrast to fibroblasts, epithelial cells spontaneously escape from senescence and develop clones of mutated, transformed, and tumorigenic cells. Recently, we revealed that accumulation of unrepaired DNA single-strand breaks is a trigger of the p16 (CDKN2)-dependent cell cycle arrest pathway in senescent epithelial cells and also the mutagenic motor of post-senescence neoplastic escape.