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10.1080/23723556.2016.1203471

http://scihub22266oqcxt.onion/10.1080/23723556.2016.1203471
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C5068178!5068178!27857971
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suck abstract from ncbi


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pmid27857971      Mol+Cell+Oncol 2016 ; 3 (5): ä
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  • Cyclin D1 promotes tumor cell invasion and metastasis by cytoplasmic mechanisms #MMPMID27857971
  • Fusté NP; Ferrezuelo F; Garí E
  • Mol Cell Oncol 2016[]; 3 (5): ä PMID27857971show ga
  • Amplification of cyclin D1 is a frequent alteration in many cancers of different type and origin. We recently described a novel regulatory axis involving cyclin D1 in the regulation of tumor invasion and metastasis. Membrane-associated cyclin D1-CDK4 complexes promote activation of the small GTPase RAC1 through phosphorylation of the regulatory protein paxillin.
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