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10.1089/aid.2016.0082

http://scihub22266oqcxt.onion/10.1089/aid.2016.0082
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C5067835!5067835!27353255
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suck abstract from ncbi


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pmid27353255      AIDS+Res+Hum+Retroviruses 2016 ; 32 (10-11): 1097-9
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  • Short Communication: HIV Controller T Cells Effectively Inhibit Viral Replication in Alveolar Macrophages #MMPMID27353255
  • Walker-Sperling VE; Merlo CA; Buckheit RW; Lambert A; Tarwater P; Kirk GD; Drummond MB; Blankson JN
  • AIDS Res Hum Retroviruses 2016[Nov]; 32 (10-11): 1097-9 PMID27353255show ga
  • Macrophages are targets of HIV-1 infection, and control of viral replication within these cells may be an important component of a T-cell-based vaccine. Although several studies have analyzed the ability of CD8+ T cells to inhibit viral replication in monocyte-derived macrophages, the effect of T cells on HIV-1-infected tissue macrophages is less clear. We demonstrate here that both CD4+ and CD8+ T-cell effectors from HIV controllers are capable of suppressing viral replication in bronchoalveolar lavage-derived alveolar macrophages. These findings have implications for HIV-1 vaccine and eradication strategies.
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