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10.3389/fphar.2016.00340 http://scihub22266oqcxt.onion/10.3389/fphar.2016.00340 C5067815!5067815!27803666     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Pharmacol 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27803666|t=2016. Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology |pdf=|usr=}}{{27803666}} gab.com Text Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology JO: Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27803666 #FOAvip Inhibitors of MAO-A and MAO-B are in clinical use for the treatment of psychiatric and neurological disorders respectively. Elucidation of the molecular structure of the active sites of the enzymes has enabled a precise determination of the way in which substrates and inhibitor molecules are metabolized, or inhibit metabolism of substrates, respectively. Despite the knowledge of the strong antidepressant efficacy of irreversible MAO inhibitors, their clinical use has been limited by their side effect of potentiation of the cardiovascular effects of dietary amines (?cheese effect?). A number of reversible MAO-A inhibitors which are devoid of cheese effect have been described in the literature, but only one, moclobemide, is currently in clinical use. The irreversible inhibitors of MAO-B, selegiline and rasagiline, are used clinically in treatment of Parkinson's disease, and a recently introduced reversible MAO-B inhibitor, safinamide, has also been found efficacious. Modification of the pharmacokinetic characteristics of selegiline by transdermal administration has led to the development of a new drug form for treatment of depression. The clinical potential of MAO inhibitors together with detailed knowledge of the enzyme's binding site structure should lead to future developments with these drugs. Twit Text FOAVip Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology ????Front Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27803666 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27803666 #FOAvip English Wikipedia <ref>{{Cite pmid|27803666}}</ref> Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology #MMPMID27803666 Finberg JPM; Rabey JM Front Pharmacol 2016[]; 7 (ä): ä PMID27803666show ga Inhibitors of MAO-A and MAO-B are in clinical use for the treatment of psychiatric and neurological disorders respectively. Elucidation of the molecular structure of the active sites of the enzymes has enabled a precise determination of the way in which substrates and inhibitor molecules are metabolized, or inhibit metabolism of substrates, respectively. Despite the knowledge of the strong antidepressant efficacy of irreversible MAO inhibitors, their clinical use has been limited by their side effect of potentiation of the cardiovascular effects of dietary amines (?cheese effect?). A number of reversible MAO-A inhibitors which are devoid of cheese effect have been described in the literature, but only one, moclobemide, is currently in clinical use. The irreversible inhibitors of MAO-B, selegiline and rasagiline, are used clinically in treatment of Parkinson's disease, and a recently introduced reversible MAO-B inhibitor, safinamide, has also been found efficacious. Modification of the pharmacokinetic characteristics of selegiline by transdermal administration has led to the development of a new drug form for treatment of depression. The clinical potential of MAO inhibitors together with detailed knowledge of the enzyme's binding site structure should lead to future developments with these drugs. äInhibitors of MAO-A and MAO-B in Psychiatry and Neurology (epmc).pdf DeepDyve Pubget Overpricing