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10.1002/ana.24602 http://scihub22266oqcxt.onion/10.1002/ana.24602 C5067647!5067647!26754410     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Neurol 2016 ; 79 (4): 560-8 Nephropedia Template TP {{tp|p=26754410|t=2016. Comparative Effectiveness of Prestroke Aspirin on Stroke Severity and Outcome |pdf=|usr=}}{{26754410}} gab.com Text Comparative Effectiveness of Prestroke Aspirin on Stroke Severity and Outcome JO: Ann Neurol http://www.kidney.de/pget.php?&tw=1&pmid=26754410 #FOAvip Objective: The effect of prestroke aspirin use on initial severity, hemorrhagic transformation, and functional outcome of ischemic stroke is uncertain. Methods: Using a multicenter stroke registry database, patients with acute ischemic stroke of three subtypes (large artery atherosclerosis [LAA], small vessel occlusion [SVO], or cardioembolism [CE]) were identified. NIH stroke scale (NIHSS) and hemorrhagic transformation at presentation and discharge modified Rankin Scale (mRS) were compared between prestroke aspirin users and nonusers. Results: Among the 10,433 patients, 1,914 (18.3%) reported prestroke aspirin use. On crude analysis, initial NIHSS scores of aspirin users were higher than nonusers (mean difference: 0.35; 95% confidence interval [CI]: 0.04?0.66). However, a multivariable analysis with an application of inverse probability of treatment weighting based on a propensity score of prestroke aspirin, having an interaction effect of prestroke aspirin use and stroke subtype in the model, showed less stroke severity for aspirin users in LAA, but not in SVO and CE than for nonusers; mean difference in NIHSS scores in LAA was ?0.97 (95% CI: ?1.45 to ?0.49). With respect to hemorrhagic transformation and mRS, no significant interaction effects were found. Prestroke aspirin use increased the risk of hemorrhagic transformation (adjusted odd ratio: 1.34; 95% CI: 1.05?1.73), but decreased the odds of the higher discharge mRS (0.86; 0.76?0.96). Interpretation: Prestroke aspirin use may reduce initial stroke severity in atherothrombotic stroke and can improve functional outcome at discharge despite an increase of hemorrhagic transformation irrespective of stroke subtype. Ann Neurol 2016;79:560?568 Twit Text FOAVip Comparative Effectiveness of Prestroke Aspirin on Stroke Severity and Outcome ????Ann Neurol http://www.kidney.de/pget.php?&tw=1&pmid=26754410 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26754410 #FOAvip English Wikipedia <ref>{{Cite pmid|26754410}}</ref> Comparative Effectiveness of Prestroke Aspirin on Stroke Severity and Outcome #MMPMID26754410 Park J; Kang K; Cho Y; Hong K; Lee KB; Park TH; Lee SJ; Ko Y; Han M; Lee J; Cha J; Kim D; Kim D; Kim J; Choi JC; Yu K; Lee B; Lee JS; Lee J; Gorelick PB; Bae H Ann Neurol 2016[Apr]; 79 (4): 560-8 PMID26754410show ga Objective: The effect of prestroke aspirin use on initial severity, hemorrhagic transformation, and functional outcome of ischemic stroke is uncertain. Methods: Using a multicenter stroke registry database, patients with acute ischemic stroke of three subtypes (large artery atherosclerosis [LAA], small vessel occlusion [SVO], or cardioembolism [CE]) were identified. NIH stroke scale (NIHSS) and hemorrhagic transformation at presentation and discharge modified Rankin Scale (mRS) were compared between prestroke aspirin users and nonusers. Results: Among the 10,433 patients, 1,914 (18.3%) reported prestroke aspirin use. On crude analysis, initial NIHSS scores of aspirin users were higher than nonusers (mean difference: 0.35; 95% confidence interval [CI]: 0.04?0.66). However, a multivariable analysis with an application of inverse probability of treatment weighting based on a propensity score of prestroke aspirin, having an interaction effect of prestroke aspirin use and stroke subtype in the model, showed less stroke severity for aspirin users in LAA, but not in SVO and CE than for nonusers; mean difference in NIHSS scores in LAA was ?0.97 (95% CI: ?1.45 to ?0.49). With respect to hemorrhagic transformation and mRS, no significant interaction effects were found. Prestroke aspirin use increased the risk of hemorrhagic transformation (adjusted odd ratio: 1.34; 95% CI: 1.05?1.73), but decreased the odds of the higher discharge mRS (0.86; 0.76?0.96). Interpretation: Prestroke aspirin use may reduce initial stroke severity in atherothrombotic stroke and can improve functional outcome at discharge despite an increase of hemorrhagic transformation irrespective of stroke subtype. Ann Neurol 2016;79:560?568 äComparative Effectiveness of Prestroke Aspirin on Stroke Severity and (epmc).pdf DeepDyve Pubget Overpricing