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10.3389/fphys.2016.00467 http://scihub22266oqcxt.onion/10.3389/fphys.2016.00467 C5067537!5067537 !27803673     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27803673 &cmd=llinks): Failed to open stream: HTTP request failed! 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Electrophysiological Mechanisms of Brugada Syndrome: Insights from Pre-clinical and Clinical Studies |pdf=|usr=}}{{27803673 }} gab.com Text Electrophysiological Mechanisms of Brugada Syndrome: Insights from Pre-clinical and Clinical Studies JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27803673 #FOAvip Brugada syndrome (BrS), is a primary electrical disorder predisposing affected individuals to sudden cardiac death via the development of ventricular tachycardia and fibrillation (VT/VF). Originally, BrS was linked to mutations in the SCN5A, which encodes for the cardiac Na(+) channel. To date, variants in 19 genes have been implicated in this condition, with 11, 5, 3, and 1 genes affecting the Na(+), K(+), Ca(2+), and funny currents, respectively. Diagnosis of BrS is based on ECG criteria of coved- or saddle-shaped ST segment elevation and/or T-wave inversion with or without drug challenge. Three hypotheses based on abnormal depolarization, abnormal repolarization, and current-load-mismatch have been put forward to explain the electrophysiological mechanisms responsible for BrS. Evidence from computational modeling, pre-clinical, and clinical studies illustrates that molecular abnormalities found in BrS lead to alterations in excitation wavelength (?), which ultimately elevates arrhythmic risk. A major challenge for clinicians in managing this condition is the difficulty in predicting the subset of patients who will suffer from life-threatening VT/VF. Several repolarization risk markers have been used thus far, but these neglect the contributions of conduction abnormalities in the form of slowing and dispersion. Indices incorporating both repolarization and conduction and based on the concept of ? have recently been proposed. These may have better predictive values than the existing markers. Twit Text FOAVip Electrophysiological Mechanisms of Brugada Syndrome: Insights from Pre-clinical and Clinical Studies ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27803673 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27803673 #FOAvip English Wikipedia <ref>{{Cite pmid|27803673 }}</ref> Electrophysiological Mechanisms of Brugada Syndrome: Insights from Pre-clinical and Clinical Studies #MMPMID27803673 Tse G ; Liu T ; Li KH ; Laxton V ; Chan YW ; Keung W ; Li RA ; Yan BP Front Physiol 2016[]; 7 (ä): 467 PMID27803673 show ga Brugada syndrome (BrS), is a primary electrical disorder predisposing affected individuals to sudden cardiac death via the development of ventricular tachycardia and fibrillation (VT/VF). Originally, BrS was linked to mutations in the SCN5A, which encodes for the cardiac Na(+) channel. To date, variants in 19 genes have been implicated in this condition, with 11, 5, 3, and 1 genes affecting the Na(+), K(+), Ca(2+), and funny currents, respectively. Diagnosis of BrS is based on ECG criteria of coved- or saddle-shaped ST segment elevation and/or T-wave inversion with or without drug challenge. Three hypotheses based on abnormal depolarization, abnormal repolarization, and current-load-mismatch have been put forward to explain the electrophysiological mechanisms responsible for BrS. Evidence from computational modeling, pre-clinical, and clinical studies illustrates that molecular abnormalities found in BrS lead to alterations in excitation wavelength (?), which ultimately elevates arrhythmic risk. A major challenge for clinicians in managing this condition is the difficulty in predicting the subset of patients who will suffer from life-threatening VT/VF. Several repolarization risk markers have been used thus far, but these neglect the contributions of conduction abnormalities in the form of slowing and dispersion. Indices incorporating both repolarization and conduction and based on the concept of ? have recently been proposed. These may have better predictive values than the existing markers. äElectrophysiological Mechanisms of Brugada Syndrome: Insights from Pre(epmc).pdf DeepDyve Pubget Overpricing