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10.3389/fnbeh.2016.00202 http://scihub22266oqcxt.onion/10.3389/fnbeh.2016.00202 C5067522!5067522!27803654     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Behav+Neurosci 2016 ; 10 (ä): ä Nephropedia Template TP {{tp|p=27803654|t=2016. Reduced Prepulse Inhibition as a Biomarker of Schizophrenia |pdf=|usr=}}{{27803654}} gab.com Text Reduced Prepulse Inhibition as a Biomarker of Schizophrenia JO: Front Behav Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=27803654 #FOAvip The startle response is composed by a set of reflex behaviors intended to prepare the organism to face a potentially relevant stimulus. This response can be modulated by several factors as, for example, repeated presentations of the stimulus (startle habituation), or by previous presentation of a weak stimulus (Prepulse Inhibition [PPI]). Both phenomena appear disrupted in schizophrenia that is thought to reflect an alteration in dopaminergic and glutamatergic neurotransmission. In this paper we analyze whether the reported deficits are indicating a transient effect restricted to the acute phase of the disease, or if it reflects a more general biomarker or endophenotype of the disorder. To this end, we measured startle responses in the same set of thirteen schizophrenia patients with a cross-sectional design at two periods: 5 days after hospital admission and 3 months after discharge. The results showed that both startle habituation and PPI were impaired in the schizophrenia patients at the acute stage as compared to a control group composed by 13 healthy participants, and that PPI but not startle habituation remained disrupted when registered 3 months after the discharge. These data point to the consideration of PPI, but not startle habituation, as a schizophrenia biomarker. Twit Text FOAVip Reduced Prepulse Inhibition as a Biomarker of Schizophrenia ????Front Behav Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=27803654 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27803654 #FOAvip English Wikipedia <ref>{{Cite pmid|27803654}}</ref> Reduced Prepulse Inhibition as a Biomarker of Schizophrenia #MMPMID27803654 Mena A; Ruiz-Salas JC; Puentes A; Dorado I; Ruiz-Veguilla M; De la Casa LG Front Behav Neurosci 2016[]; 10 (ä): ä PMID27803654show ga The startle response is composed by a set of reflex behaviors intended to prepare the organism to face a potentially relevant stimulus. This response can be modulated by several factors as, for example, repeated presentations of the stimulus (startle habituation), or by previous presentation of a weak stimulus (Prepulse Inhibition [PPI]). Both phenomena appear disrupted in schizophrenia that is thought to reflect an alteration in dopaminergic and glutamatergic neurotransmission. In this paper we analyze whether the reported deficits are indicating a transient effect restricted to the acute phase of the disease, or if it reflects a more general biomarker or endophenotype of the disorder. To this end, we measured startle responses in the same set of thirteen schizophrenia patients with a cross-sectional design at two periods: 5 days after hospital admission and 3 months after discharge. The results showed that both startle habituation and PPI were impaired in the schizophrenia patients at the acute stage as compared to a control group composed by 13 healthy participants, and that PPI but not startle habituation remained disrupted when registered 3 months after the discharge. These data point to the consideration of PPI, but not startle habituation, as a schizophrenia biomarker. äReduced Prepulse Inhibition as a Biomarker of Schizophrenia (epmc).pdf DeepDyve Pubget Overpricing