Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Wiley+Interdiscip+Rev+RNA 2016 ; 7 (4): 428-37 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Prohead RNA: a noncoding viral RNA of novel structure and function #MMPMID26810250
Hill AC; Bartley LE; Schroeder SJ
Wiley Interdiscip Rev RNA 2016[Jul]; 7 (4): 428-37 PMID26810250show ga
Prohead RNA (pRNA) is an essential component of the powerful ?29?like bacteriophage DNA packaging motor. However, the specific role of this unique RNA in the ?29 packaging motor remains unknown. This review examines pRNA as a noncoding RNA of novel structure and function. In order to highlight the reasons for exploring the structure and function of pRNA, we (1) provide an overview of ?29?like bacteriophage and the ?29 DNA packaging motor, including putative motor mechanisms and structures of its component parts; (2) discuss pRNA structure and possible roles for pRNA in the ?29 packaging motor; (3) summarize pRNA self?assembly; and (4) describe the prospective therapeutic applications of pRNA. Many questions remain to be answered in order to connect what is currently known about pRNA structure to its novel function in the ?29 packaging motor. The knowledge gained from studying the structure, function, and sequence variation in pRNA will help develop tools to better navigate the conformational landscapes of RNA. WIREs RNA 2016, 7:428?437. doi: 10.1002/wrna.1330For further resources related to this article, please visit the WIREs website.