Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27800020
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27800020
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ther+Adv+Neurol+Disord
2016 ; 9
(6
): 445-453
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Two-year real-world experience with perampanel in patients with refractory focal
epilepsy: Austrian data
#MMPMID27800020
Rohracher A
; Kalss G
; Leitinger M
; Granbichler C
; Deak I
; Dobesberger J
; Kuchukhidze G
; Thomschewski A
; Höfler J
; Trinka E
Ther Adv Neurol Disord
2016[Nov]; 9
(6
): 445-453
PMID27800020
show ga
BACKGROUND: The aim of this study was to analyse registry data of seizure outcome
and adverse events (AEs) for perampanel as add-on therapy in patients with focal
epilepsy since its approval in 2012 for adjunctive treatment of focal epilepsy in
patients ?12 years. METHOD: A retrospective 2-year chart review of all patients
receiving perampanel was carried out. RESULTS: A total of 122 patients received
perampanel [median treatment length: 20.1 (range: 3.4-26.8) months]; 71 (58%)
remained on treatment at last follow up. Overall, 33 patients (27%) were
seizure-free for ?3 months at last follow up; of these, eight were seizure free
for ?3 times the longest interictal interval before perampanel therapy; 18 (15%)
had reduced seizure frequency ?50%. A total of 58 (47%) had an AE and 34 (28%)
withdrew from treatment because of AEs. AEs included dizziness (33%), fatigue
(12%), psychiatric symptoms (8%), cognitive deficits (7%), speech problems (5%),
nausea (4%) and gait problems (4%). AEs subsided in 17/18 patients (94%)
following a 2 mg dose reduction. A total of 43 (35%) took a concomitant enzyme
inducer. Patients not taking enzyme inducers were more likely to be seizure free
(p = 0.002); there were no other between-group differences. CONCLUSIONS:
Perampanel was well tolerated and improved seizure control in 42% of patients
(50- 100% reduction), with higher rates in those not receiving a concomitant
enzyme inducer. AEs, particularly dizziness, were common but often disappeared
with a slight dose reduction. The results are consistent with those from
randomized controlled trials.
free
free
free
