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2015 ; 1
(ä): 4
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Diabetes induces changes in neuroretina before retinal vessels: a spectral-domain
optical coherence tomography study
#MMPMID27847597
Rodrigues EB
; Urias MG
; Penha FM
; Badaró E
; Novais E
; Meirelles R
; Farah ME
Int J Retina Vitreous
2015[]; 1
(ä): 4
PMID27847597
show ga
PURPOSE: To investigate retinal changes prior to vascular signs in patients with
type 2 diabetes without diabetic retinopathy or with mild non proliferative
diabetic retinopathy. METHODS: A cross-sectional study was performed in three
groups: patients without diabetes, patients with type 2 diabetes without diabetic
retinopathy, and patients with diabetes with mild diabetic retinopathy. Analysis
of retinal layers was performed objectively with the Cirrus Review Software 6.0
(Carl Zeiss Meditec, Dublin, CA, USA). Macular cube scans were analyzed with
regard to: the ganglion cell layer?+?inner plexiform layer analysis, retinal
nerve fiber layer thickness, central subfoveal retinal thickness and average
macular thickness. RESULTS: In total, 102 patients were included in this study,
of which 28 (27.4%) were classified into control group, 46 (45.0%) classified as
diabetic patients with no diabetic retinopathy and 28 (27.4%) classified as mild
diabetic retinopathy. Quantitative analysis with the Cirrus software showed that
the mean ganglion cell layer and mean retinal nerve fiber layer were thinner in
diabetes without diabetic retinopathy group when compared to controls. ANOVA with
Bonferroni post test indicated a statistically significant reduction in average
retinal thickness in mild diabetic retinopathy group (P?=?0.032) compared to
control and reduction in ganglion cell layer in diabetes with no diabetic
retinopathy (P?=?0.039) and mild diabetic retinopathy (P?=?0.003). Also indicated
reduction in retinal nerve fiber layer in diabetic without diabetic retinopathy
and eyes with mild diabetic retinopathy (P?0.001), compared to controls.
CONCLUSIONS: Our study found reduction in thickness of ganglion cell layer and
retinal nerve fiber layer in patients with diabetes without diabetic retinopathy,
which suggests neuroretinal changes before vascular signs of diabetic
retinopathy.