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10.1016/j.kint.2016.05.019 http://scihub22266oqcxt.onion/10.1016/j.kint.2016.05.019 C5065745!5065745 !27457912     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27457912 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Kidney+Int 2016 ; 90 (5 ): 985-996 Nephropedia Template TP {{tp|p=27457912 |t=2016. Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease |pdf=|usr=}}{{27457912 }} gab.com Text Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=27457912 #FOAvip Patients with chronic kidney disease (CKD) develop increased levels of the phosphate-regulating hormone, fibroblast growth factor (FGF) 23, that are associated with a higher risk of mortality. Increases in inflammatory markers are another common feature that predicts poor clinical outcomes. Elevated FGF23 is associated with higher circulating levels of inflammatory cytokines in CKD, which can stimulate osteocyte production of FGF23. Here, we studied whether FGF23 can directly stimulate hepatic production of inflammatory cytokines in the absence of ?-klotho, an FGF23 coreceptor in the kidney that is not expressed by hepatocytes. By activating FGF receptor isoform 4 (FGFR4), FGF23 stimulated calcineurin signaling in cultured hepatocytes, which increased the expression and secretion of inflammatory cytokines, including C-reactive protein. Elevating serum FGF23 levels increased hepatic and circulating levels of C-reactive protein in wild-type mice, but not in FGFR4 knockout mice. Administration of an isoform-specific FGFR4 blocking antibody reduced hepatic and circulating levels of C-reactive protein in the 5/6 nephrectomy rat model of CKD. Thus, FGF23 can directly stimulate hepatic secretion of inflammatory cytokines. Our findings indicate a novel mechanism of chronic inflammation in patients with CKD and suggest that FGFR4 blockade might have therapeutic anti-inflammatory effects in CKD. Twit Text FOAVip Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=27457912 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27457912 #FOAvip English Wikipedia <ref>{{Cite pmid|27457912 }}</ref> Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease #MMPMID27457912 Singh S ; Grabner A ; Yanucil C ; Schramm K ; Czaya B ; Krick S ; Czaja MJ ; Bartz R ; Abraham R ; Di Marco GS ; Brand M ; Wolf M ; Faul C Kidney Int 2016[Nov]; 90 (5 ): 985-996 PMID27457912 show ga Patients with chronic kidney disease (CKD) develop increased levels of the phosphate-regulating hormone, fibroblast growth factor (FGF) 23, that are associated with a higher risk of mortality. Increases in inflammatory markers are another common feature that predicts poor clinical outcomes. Elevated FGF23 is associated with higher circulating levels of inflammatory cytokines in CKD, which can stimulate osteocyte production of FGF23. Here, we studied whether FGF23 can directly stimulate hepatic production of inflammatory cytokines in the absence of ?-klotho, an FGF23 coreceptor in the kidney that is not expressed by hepatocytes. By activating FGF receptor isoform 4 (FGFR4), FGF23 stimulated calcineurin signaling in cultured hepatocytes, which increased the expression and secretion of inflammatory cytokines, including C-reactive protein. Elevating serum FGF23 levels increased hepatic and circulating levels of C-reactive protein in wild-type mice, but not in FGFR4 knockout mice. Administration of an isoform-specific FGFR4 blocking antibody reduced hepatic and circulating levels of C-reactive protein in the 5/6 nephrectomy rat model of CKD. Thus, FGF23 can directly stimulate hepatic secretion of inflammatory cytokines. Our findings indicate a novel mechanism of chronic inflammation in patients with CKD and suggest that FGFR4 blockade might have therapeutic anti-inflammatory effects in CKD. |Animals [MESH] |Calcineurin/metabolism [MESH] |Cytokines/*metabolism [MESH] |Fibroblast Growth Factor-23 [MESH] |Fibroblast Growth Factors/*metabolism [MESH] |Glucuronidase/metabolism [MESH] |Hepatocytes/*metabolism [MESH] |Humans [MESH] |Inflammation/*metabolism [MESH] |Klotho Proteins [MESH] |Mice [MESH] |NFATC Transcription Factors/metabolism [MESH] |Phospholipase C gamma/metabolism [MESH] |Primary Cell Culture [MESH] |Rats [MESH] |Receptor, Fibroblast Growth Factor, Type 4/metabolism [MESH] |Renal Insufficiency, Chronic/*metabolism [MESH]Fibroblast growth factor 23 directly targets hepatocytes to promote in(epmc).pdf DeepDyve Pubget Overpricing