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10.1128/MCB.00160-16 http://scihub22266oqcxt.onion/10.1128/MCB.00160-16 C5064215!5064215!27528616     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Biol 2016 ; 36 (21): 2668-80 Nephropedia Template TP {{tp|p=27528616|t=2016. BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis |pdf=|usr=}}{{27528616}} gab.com Text BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27528616 #FOAvip Chibby1 (Cby1) is a small, conserved coiled-coil protein that localizes to centrioles/basal bodies and plays a crucial role in the formation and function of cilia. During early stages of ciliogenesis, Cby1 is required for the efficient recruitment of small vesicles at the distal end of centrioles to facilitate basal body docking to the plasma membrane. Here, we identified family with sequence similarity 92, member A (FAM92A) and FAM92B, which harbor predicted lipid-binding BAR domains, as novel Cby1-interacting partners using tandem affinity purification and mass spectrometry. We found that in cultured cell lines, FAM92A colocalizes with Cby1 at the centrioles/basal bodies of primary cilia, while FAM92B is undetectable. In airway multiciliated cells, both FAM92A and -92B colocalize with Cby1 at the base of cilia. Notably, the centriolar localization of FAM92A and -92B depends largely on Cby1. Knockdown of FAM92A in RPE1 cells impairs ciliogenesis. Consistent with the membrane-remodeling properties of BAR domains, FAM92A and -92B in cooperation with Cby1 induce deformed membrane-like structures containing the small GTPase Rab8 in cultured cells. Our results therefore suggest that FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling processes. Twit Text FOAVip BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27528616 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27528616 #FOAvip English Wikipedia <ref>{{Cite pmid|27528616}}</ref> BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis #MMPMID27528616 Li FQ; Chen X; Fisher C; Siller SS; Zelikman K; Kuriyama R; Takemaru KI Mol Cell Biol 2016[Nov]; 36 (21): 2668-80 PMID27528616show ga Chibby1 (Cby1) is a small, conserved coiled-coil protein that localizes to centrioles/basal bodies and plays a crucial role in the formation and function of cilia. During early stages of ciliogenesis, Cby1 is required for the efficient recruitment of small vesicles at the distal end of centrioles to facilitate basal body docking to the plasma membrane. Here, we identified family with sequence similarity 92, member A (FAM92A) and FAM92B, which harbor predicted lipid-binding BAR domains, as novel Cby1-interacting partners using tandem affinity purification and mass spectrometry. We found that in cultured cell lines, FAM92A colocalizes with Cby1 at the centrioles/basal bodies of primary cilia, while FAM92B is undetectable. In airway multiciliated cells, both FAM92A and -92B colocalize with Cby1 at the base of cilia. Notably, the centriolar localization of FAM92A and -92B depends largely on Cby1. Knockdown of FAM92A in RPE1 cells impairs ciliogenesis. Consistent with the membrane-remodeling properties of BAR domains, FAM92A and -92B in cooperation with Cby1 induce deformed membrane-like structures containing the small GTPase Rab8 in cultured cells. Our results therefore suggest that FAM92 proteins interact with Cby1 to promote ciliogenesis via regulation of membrane-remodeling processes. äBAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilita(epmc).pdf DeepDyve Pubget Overpricing