Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/bcp.13059 http://scihub22266oqcxt.onion/10.1111/bcp.13059 C5061791!5061791 !27426428     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27426428 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Br+J+Clin+Pharmacol 2016 ; 82 (5 ): 1291-1302 Nephropedia Template TP {{tp|p=27426428 |t=2016. Hypoglycaemia when adding sulphonylurea to metformin: a systematic review and network meta-analysis |pdf=|usr=}}{{27426428 }} gab.com Text Hypoglycaemia when adding sulphonylurea to metformin: a systematic review and network meta-analysis JO: Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27426428 #FOAvip AIMS: The risk of hypoglycaemia may differ among sulphonylureas (SUs), but evidence from head-to-head comparisons is sparse. Performing a network meta-analysis to use indirect evidence from randomized controlled trials (RCTs), we compared the relative risk of hypoglycaemia with newer generation SUs when added to metformin. METHODS: A systematic review identified RCTs lasting 12-52 weeks and evaluating SUs added to inadequate metformin monotherapy (?1000 mg/day) in type 2 diabetes. Adding RCTs investigating the active comparators from the identified SU trials, we established a coherent network. Hypoglycaemia of any severity was the primary end point. RESULTS: Thirteen trials of SUs and 14 of oral non-SU antihyperglycaemic agents (16?260 patients) were included. All reported hypoglycaemia only as adverse events. Producing comparable reductions in HbA(1C) of -0.66 to -0.84% (-7 to -9 mmol/mol), the risk of hypoglycaemia was lowest with gliclazide compared to glipizide (OR 0.22, CrI: 0.05 to 0.96), glimepiride (OR 0.40, CrI: 0.13 to 1.27), and glibenclamide (OR 0.21, CrI: 0.03 to 1.48). A major limitation is varying definitions of hypoglycaemia across studies. CONCLUSIONS: When added to metformin, gliclazide was associated with the lowest risk of hypoglycaemia between the newer generation SUs. Clinicians should consider the risk of hypoglycaemia agent-specific when selecting an SU agent. Twit Text FOAVip Hypoglycaemia when adding sulphonylurea to metformin: a systematic review and network meta-analysis ????Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27426428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27426428 #FOAvip English Wikipedia <ref>{{Cite pmid|27426428 }}</ref> Hypoglycaemia when adding sulphonylurea to metformin: a systematic review and network meta-analysis #MMPMID27426428 Andersen SE ; Christensen M Br J Clin Pharmacol 2016[Nov]; 82 (5 ): 1291-1302 PMID27426428 show ga AIMS: The risk of hypoglycaemia may differ among sulphonylureas (SUs), but evidence from head-to-head comparisons is sparse. Performing a network meta-analysis to use indirect evidence from randomized controlled trials (RCTs), we compared the relative risk of hypoglycaemia with newer generation SUs when added to metformin. METHODS: A systematic review identified RCTs lasting 12-52 weeks and evaluating SUs added to inadequate metformin monotherapy (?1000 mg/day) in type 2 diabetes. Adding RCTs investigating the active comparators from the identified SU trials, we established a coherent network. Hypoglycaemia of any severity was the primary end point. RESULTS: Thirteen trials of SUs and 14 of oral non-SU antihyperglycaemic agents (16?260 patients) were included. All reported hypoglycaemia only as adverse events. Producing comparable reductions in HbA(1C) of -0.66 to -0.84% (-7 to -9 mmol/mol), the risk of hypoglycaemia was lowest with gliclazide compared to glipizide (OR 0.22, CrI: 0.05 to 0.96), glimepiride (OR 0.40, CrI: 0.13 to 1.27), and glibenclamide (OR 0.21, CrI: 0.03 to 1.48). A major limitation is varying definitions of hypoglycaemia across studies. CONCLUSIONS: When added to metformin, gliclazide was associated with the lowest risk of hypoglycaemia between the newer generation SUs. Clinicians should consider the risk of hypoglycaemia agent-specific when selecting an SU agent. |Diabetes Mellitus, Type 2/drug therapy [MESH] |Drug Therapy, Combination/adverse effects [MESH] |Humans [MESH] |Hypoglycemia/*chemically induced [MESH] |Hypoglycemic Agents/adverse effects [MESH] |Metformin/*adverse effects/therapeutic use [MESH]Hypoglycaemia when adding sulphonylurea to metformin: a systematic rev(epmc).pdf DeepDyve Pubget Overpricing