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10.1007/s11255-016-1224-0

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suck abstract from ncbi


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pmid26886110
      Int+Urol+Nephrol 2016 ; 48 (5 ): 725-9
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  • Back to the future: restricted protein intake for conservative management of CKD, triple goals of renoprotection, uremia mitigation, and nutritional health #MMPMID26886110
  • Kovesdy CP ; Kalantar-Zadeh K
  • Int Urol Nephrol 2016[May]; 48 (5 ): 725-9 PMID26886110 show ga
  • Lowering dietary protein intake (DPI) to approximately 0.6-0.8 g/kgBW/day may be renoprotective through various mechanisms, and it has been recommended in patients with non-dialysis-dependent chronic kidney disease (NDD-CKD) as a means to also control various metabolic consequences of advanced CKD, such as uremic symptoms, hyperparathyroidism, hypertension, hyperkalemia, and hyperphosphatemia. A meta-analysis in this issue of the Journal suggests that low-protein diet is effective and safe when used to retard progression of CKD and alleviate uremic complications. A potential deleterious consequence of lowering DPI in this population is the development or worsening of protein-energy wasting (PEW), which can contribute to poor clinical outcomes such as higher mortality and morbidity. There is currently insufficient high-level evidence to determine the ideal level of DPI in patients with NDD-CKD with high risk of PEW. For the time being we recommend a DPI of 0.6-0.8 g/kgBW/day, and increasing this as needed on an individual basis in patients with PEW. Further examination of this dilemma in randomized controlled clinical trials will be necessary.
  • |*Diet, Protein-Restricted/adverse effects [MESH]
  • |Conservative Treatment/methods [MESH]
  • |Goals [MESH]
  • |Humans [MESH]
  • |Nutritional Requirements [MESH]
  • |Nutritional Status [MESH]
  • |Protein-Energy Malnutrition/*etiology/prevention & control [MESH]
  • |Renal Insufficiency/complications/*diet therapy [MESH]


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