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2015 ; 94
(47
): e2107
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Organophosphate Poisoning and Subsequent Acute Kidney Injury Risk: A Nationwide
Population-Based Cohort Study
#MMPMID26632728
Lee FY
; Chen WK
; Lin CL
; Lai CY
; Wu YS
; Lin IC
; Kao CH
Medicine (Baltimore)
2015[Nov]; 94
(47
): e2107
PMID26632728
show ga
Small numbers of the papers have studied the association between organophosphate
(OP) poisoning and the subsequent acute kidney injury (AKI). Therefore, we used
the National Health Insurance Research Database (NHIRD) to study whether patients
with OP poisoning are associated with a higher risk to have subsequent AKI.The
retrospective cohort study comprised patients aged ?20 years with OP poisoning
and hospitalized diagnosis during 2000-2011 (N = 8924). Each OP poisoning patient
was frequency-matched to 4 control patients based on age, sex, index year, and
comorbidities of diabetes, hypertension, hyperlipidemia, chronic obstructive
pulmonary disease, coronary artery disease, and stroke (N = 35,696). We conducted
Cox proportional hazard regression analysis to estimate the effects of OP
poisoning on AKI risk.The overall incidence of AKI was higher in the patients
with OP poisoning than in the controls (4.85 vs 3.47/1000 person-years). After
adjustment for age, sex, comorbidity, and interaction terms, patients with OP
poisoning were associated with a 6.17-fold higher risk of AKI compared with the
comparison cohort. Patients with highly severe OP poisoning were associated with
a substantially increased risk of AKI.The study found OP poisoning is associated
with increased risk of subsequent AKI. Future studies are encouraged to evaluate
whether long-term effects exist and the best guideline to prevent the
continuously impaired renal function.