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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 1992 ; 89 (23): 11486-9 Nephropedia Template TP
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Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells #MMPMID1454837
Briese T; de la Torre JC; Lewis A; Ludwig H; Lipkin WI
Proc Natl Acad Sci U S A 1992[Dec]; 89 (23): 11486-9 PMID1454837show ga
Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Borna disease virus is a single-stranded RNA virus. We describe here a method for isolation of viral particles that has allowed definitive identification of the genome as containing a negative-polarity RNA. Further, we show that the viral mRNAs are transcribed in the nucleus.Images: