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10.1002/cpt.435 http://scihub22266oqcxt.onion/10.1002/cpt.435 C5056151!5056151!27447939     free     free     free       Clin+Pharmacol+Ther 2016 ; 100 (5): 441-53 Nephropedia Template TP {{tp|p=27447939|t=2016. Transporters as Drug Targets in Neurological Diseases |pdf=|usr=}}{{27447939}} gab.com Text Transporters as Drug Targets in Neurological Diseases JO: Clin Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=27447939 #FOAvip Membrane transport proteins have central physiological function in maintaining cerebral homeostasis. These transporters are expressed in almost all cerebral cells where they regulate the movement of wide range of solutes including endogenous substrates, xenobiotic and therapeutic drugs. Altered activity/expression of CNS transporters has been implicated in the onset and progression of multiple neurological diseases. Neurological diseases are heterogeneous diseases that involve complex pathological alterations with only a few treatment options; therefore there is a great need for the development of novel therapeutic treatments. To that end, transporters have emerged recently to be promising therapeutic targets to halt or slow the course of neurological diseases. The objective of this review is to discuss implications of transporters in neurological diseases and summarize available evidence for targeting transporters as decent therapeutic approach in the treatment of neurological diseases. Twit Text FOAVip Transporters as Drug Targets in Neurological Diseases ????Clin Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=27447939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27447939 #FOAvip English Wikipedia <ref>{{Cite pmid|27447939}}</ref> Transporters as Drug Targets in Neurological Diseases #MMPMID27447939 Qosa H; Mohamed LA; Alqahtani S; Abuasal BS; Hill RA; Kaddoumi A Clin Pharmacol Ther 2016[Nov]; 100 (5): 441-53 PMID27447939show ga Membrane transport proteins have central physiological function in maintaining cerebral homeostasis. These transporters are expressed in almost all cerebral cells where they regulate the movement of wide range of solutes including endogenous substrates, xenobiotic and therapeutic drugs. Altered activity/expression of CNS transporters has been implicated in the onset and progression of multiple neurological diseases. Neurological diseases are heterogeneous diseases that involve complex pathological alterations with only a few treatment options; therefore there is a great need for the development of novel therapeutic treatments. To that end, transporters have emerged recently to be promising therapeutic targets to halt or slow the course of neurological diseases. The objective of this review is to discuss implications of transporters in neurological diseases and summarize available evidence for targeting transporters as decent therapeutic approach in the treatment of neurological diseases. äTransporters as Drug Targets in Neurological Diseases (epmc).pdf DeepDyve Pubget Overpricing