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10.1073/pnas.1606719113 http://scihub22266oqcxt.onion/10.1073/pnas.1606719113 C5056095!5056095!27647915     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (40): E5866-75 Nephropedia Template TP {{tp|p=27647915|t=2016. Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog |pdf=|usr=}}{{27647915}} gab.com Text Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27647915 #FOAvip The Hedgehog-signaling pathway plays key roles in animal development and physiology. Insufficient Hedgehog signaling causes birth defects, whereas uncontrolled signaling is implicated in cancer. Signaling is triggered by the secreted protein, Sonic Hedgehog, which inhibits the membrane protein Patched1, leading to pathway activation. Despite its fundamental importance, we do not understand how Sonic Hedgehog inhibits Patched1. Here, we uncover a critical interaction between the fatty-acid?modified N-terminal portion of Sonic Hedgehog and Patched1, and we demonstrate that it is necessary and sufficient for Patched1 inhibition during Hedgehog signaling. This interaction explains impairment of a Sonic Hedgehog mutant causing a congenital brain malformation (holoprosencephaly) and oncogenic activity of Patched1 mutants responsible for a human cancer syndrome. Twit Text FOAVip Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27647915 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27647915 #FOAvip English Wikipedia <ref>{{Cite pmid|27647915}}</ref> Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog #MMPMID27647915 Tukachinsky H; Petrov K; Watanabe M; Salic A Proc Natl Acad Sci U S A 2016[Oct]; 113 (40): E5866-75 PMID27647915show ga The Hedgehog-signaling pathway plays key roles in animal development and physiology. Insufficient Hedgehog signaling causes birth defects, whereas uncontrolled signaling is implicated in cancer. Signaling is triggered by the secreted protein, Sonic Hedgehog, which inhibits the membrane protein Patched1, leading to pathway activation. Despite its fundamental importance, we do not understand how Sonic Hedgehog inhibits Patched1. Here, we uncover a critical interaction between the fatty-acid?modified N-terminal portion of Sonic Hedgehog and Patched1, and we demonstrate that it is necessary and sufficient for Patched1 inhibition during Hedgehog signaling. This interaction explains impairment of a Sonic Hedgehog mutant causing a congenital brain malformation (holoprosencephaly) and oncogenic activity of Patched1 mutants responsible for a human cancer syndrome. äMechanism of inhibition of the tumor suppressor Patched by Sonic Hedge(epmc).pdf DeepDyve Pubget Overpricing