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10.1073/pnas.1610347113

http://scihub22266oqcxt.onion/10.1073/pnas.1610347113
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C5056065!5056065!27663743
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suck abstract from ncbi

pmid27663743      Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (40): 11208-13
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  • Oriented collagen fibers direct tumor cell intravasation #MMPMID27663743
  • Han W; Chen S; Yuan W; Fan Q; Tian J; Wang X; Chen L; Zhang X; Wei W; Liu R; Qu J; Jiao Y; Austin RH; Liu L
  • Proc Natl Acad Sci U S A 2016[Oct]; 113 (40): 11208-13 PMID27663743show ga
  • Intravasation is an early stage of metastasis that involves metastatic cells moving from the tumor into the extracellular matrix (ECM), breakthrough of the basement membrane, and entry into blood vessels. We found that the oriented fibers greatly enhance and facilitate the metastatic cell intravasation process during metastasis. We suggest that a possible ?tissue treatment? therapy could be considered, in which the ECM fiber structure orientation in the tumor microenvironment might be altered to minimize the intravasation rate of metastatic cells.
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