Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1610735113 http://scihub22266oqcxt.onion/10.1073/pnas.1610735113 C5056041!5056041!27647897     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (40): 11243-8 Nephropedia Template TP {{tp|p=27647897|t=2016. BMI1?UBR5 axis regulates transcriptional repression at damaged chromatin |pdf=|usr=}}{{27647897}} gab.com Text BMI1 UBR5 axis regulates transcriptional repression at damaged chromatin JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27647897 #FOAvip The BMI1-containing Polycomb Repressive Complex is an important gene silencer during development, stem cell maintenance, and cancer progression. BMI1 is also involved in DNA damage response, but its downstream mechanism is unclear. Here we identified UBR5 as a downstream factor whose chromatin recruitment is regulated by BMI1. We showed that BMI1 and UBR5 repress the RNA polymerase II (Pol II) elongation and nascent RNA synthesis at UV-induced DNA lesions. UBR5 associates with and regulates the abundance of the histone chaperon complex FACT at damaged chromatin and regulates elongation of Pol II at the lesions. Thus, our studies identify a pathway that regulates the damage-induced transcriptional repression that is governed by BMI1. Twit Text FOAVip BMI1 UBR5 axis regulates transcriptional repression at damaged chromatin ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27647897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27647897 #FOAvip English Wikipedia <ref>{{Cite pmid|27647897}}</ref> BMI1?UBR5 axis regulates transcriptional repression at damaged chromatin #MMPMID27647897 Sanchez A; De Vivo A; Uprety N; Kim J; Stevens SM; Kee Y Proc Natl Acad Sci U S A 2016[Oct]; 113 (40): 11243-8 PMID27647897show ga The BMI1-containing Polycomb Repressive Complex is an important gene silencer during development, stem cell maintenance, and cancer progression. BMI1 is also involved in DNA damage response, but its downstream mechanism is unclear. Here we identified UBR5 as a downstream factor whose chromatin recruitment is regulated by BMI1. We showed that BMI1 and UBR5 repress the RNA polymerase II (Pol II) elongation and nascent RNA synthesis at UV-induced DNA lesions. UBR5 associates with and regulates the abundance of the histone chaperon complex FACT at damaged chromatin and regulates elongation of Pol II at the lesions. Thus, our studies identify a pathway that regulates the damage-induced transcriptional repression that is governed by BMI1. äBMI1?UBR5 axis regulates transcriptional repression at damaged chromat(epmc).pdf DeepDyve Pubget Overpricing