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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Curr+Opin+Genet+Dev 2016 ; 38 (ä): 45-51 Nephropedia Template TP
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Roles of Fe-S clusters: From cofactor synthesis to iron homeostasis to protein synthesis #MMPMID27061491
Pain D; Dancis A
Curr Opin Genet Dev 2016[Jun]; 38 (ä): 45-51 PMID27061491show ga
Fe-S cluster assembly is an essential process for all cells. Impairment of Fe-S cluster assembly creates diseases in diverse and surprising ways. In one scenario, the loss of function of lipoic acid synthase, an enzyme with Fe-S cluster cofactor in mitochondria, impairs activity of various lipoamide-dependent enzymes with drastic consequences for metabolism. In a second scenario, the heme biosynthetic pathway in red cell precursors is specifically targeted, and iron homeostasis is perturbed, but lipoic acid is unaffected. In a third scenario, tRNA modifications arising from action of the cysteine desulfurase and/or Fe-S cluster proteins are lost, which may lead to impaired protein synthesis. This can then result in cancer, neurologic dysfunction or type 2 diabetes.