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10.1016/j.cels.2016.08.007 http://scihub22266oqcxt.onion/10.1016/j.cels.2016.08.007 C5055390!5055390!27667364     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Syst 2016 ; 3 (3): 252-263.e8 Nephropedia Template TP {{tp|p=27667364|t=2016. Vimentin intermediate filaments template microtubule networks to enhance persistence in cell polarity and directed migration |pdf=|usr=}}{{27667364}} gab.com Text Vimentin intermediate filaments template microtubule networks to enhance persistence in cell polarity and directed migration JO: Cell Syst http://www.kidney.de/pget.php?&tw=1&pmid=27667364 #FOAvip Increased expression of vimentin intermediate filaments (VIF) enhances directed cell migration, but the mechanism behind VIF?s effect on motility is not understood. VIF interact with microtubules, whose organization contributes to polarity maintenance in migrating cells. Here we characterize the dynamic coordination of VIF and microtubule networks in wounded monolayers of Retinal Pigment Epithelial cells. By genome editing we fluorescently labelled endogenous vimentin and ?-tubulin and we developed computational image analysis to delineate architecture and interactions of the two networks. Our results show that VIF assemble an ultrastructural copy of the previously polarized microtubule network. Because the VIF network is long-lived compared to the microtubule network, VIF template future microtubule growth along previous microtubule tracks, thus providing a feedback mechanism that maintains cell polarity. VIF knockdown prevents cells from polarizing and migrating properly during wound healing. We suggest that VIF?s templating function establishes a memory in microtubule organization that enhances persistence in cell polarization in general and migration in particular. Twit Text FOAVip Vimentin intermediate filaments template microtubule networks to enhance persistence in cell polarity and directed migration ????Cell Syst http://www.kidney.de/pget.php?&tw=1&pmid=27667364 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27667364 #FOAvip English Wikipedia <ref>{{Cite pmid|27667364}}</ref> Vimentin intermediate filaments template microtubule networks to enhance persistence in cell polarity and directed migration #MMPMID27667364 Gan Z; Ding L; Burckhardt CJ; Lowery J; Zaritsky A; Sitterley K; Mota A; Costigliola N; Starker CG; Voytas DF; Tytell J; Goldman RD; Danuser G Cell Syst 2016[Sep]; 3 (3): 252-263.e8 PMID27667364show ga Increased expression of vimentin intermediate filaments (VIF) enhances directed cell migration, but the mechanism behind VIF?s effect on motility is not understood. VIF interact with microtubules, whose organization contributes to polarity maintenance in migrating cells. Here we characterize the dynamic coordination of VIF and microtubule networks in wounded monolayers of Retinal Pigment Epithelial cells. By genome editing we fluorescently labelled endogenous vimentin and ?-tubulin and we developed computational image analysis to delineate architecture and interactions of the two networks. Our results show that VIF assemble an ultrastructural copy of the previously polarized microtubule network. Because the VIF network is long-lived compared to the microtubule network, VIF template future microtubule growth along previous microtubule tracks, thus providing a feedback mechanism that maintains cell polarity. VIF knockdown prevents cells from polarizing and migrating properly during wound healing. We suggest that VIF?s templating function establishes a memory in microtubule organization that enhances persistence in cell polarization in general and migration in particular. äVimentin intermediate filaments template microtubule networks to enhan(epmc).pdf DeepDyve Pubget Overpricing