Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26761583
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26761583
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Blood+Coagul+Fibrinolysis
2016 ; 27
(7
): 753-760
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Use of recombinant activated factor VII for acute bleeding episodes in acquired
hemophilia: final analysis from the Hemostasis and Thrombosis Research Society
Registry acquired hemophilia study
#MMPMID26761583
Ma AD
; Kessler CM
; Al-Mondhiry HA
; Gut RZ
; Cooper DL
Blood Coagul Fibrinolysis
2016[Oct]; 27
(7
): 753-760
PMID26761583
show ga
The Hemostasis and Thrombosis Research Society Registry was used to monitor the
postapproval use and safety of recombinant activated factor VII (rFVIIa). The
objective of this article is to evaluate the data from the Hemostasis and
Thrombosis Research Society Registry related to rFVIIa-treated bleeding episodes
in patients with acquired hemophilia. For each rFVIIa-treated bleeding episode,
the initial dose, total dose, average infused dose, number of doses, and
treatment duration were calculated. Efficacy was assessed on a three-point scale.
Out of the 166 registered patients with acquired hemophilia, 110 patients were
treated for 237 bleeding episodes (139 rFVIIa treated); the majority (70%) were
in patients older than 60 years. The most frequently reported bleeding locations
were subcutaneous (40%) and mucosal (32%). Subcutaneous bleeding episodes were
more commonly reported in women (55% vs. 40% men) and white patients (44 vs. 27%
black). Of the 139 rFVIIa-treated bleeding episodes, rFVIIa was used as
first-line treatment in 127 bleeding episodes. The median initial dose was
90??g/kg; the median total dose per episode was 333.5??g/kg. Physician-rated
efficacy of rFVIIa for each bleeding episode was reported as 'bleeding stopped'
in 85% of bleeding episodes, 'bleeding slowed' in 11% of bleeding episodes, 'no
improvement' in 4% of bleeding episodes, and was not documented in 1 bleeding
episode. One thromboembolic event was reported; transient neurologic symptoms
were reported in a 31-year-old postpartum patient after 110 doses of rFVIIa.
Adequate hemostasis was provided for most rFVIIa-treated bleeding episodes at
doses largely conforming to the package insert. No major safety concerns were
reported.