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10.1146/annurev-biophys-062215-010830

http://scihub22266oqcxt.onion/10.1146/annurev-biophys-062215-010830
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C5053920!5053920!27145877
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suck abstract from ncbi

pmid27145877      Annu+Rev+Biophys 2016 ; 45 (ä): 1-23
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  • Imaging Specific Genomic DNA in Living Cells #MMPMID27145877
  • Chen B; Guan J; Huang B
  • Annu Rev Biophys 2016[Jul]; 45 (ä): 1-23 PMID27145877show ga
  • The three-dimensional organization of the genome plays important roles in regulating the functional output of the genome, and even the maintenance of epigenetic inheritance and genome stability. Here, we review and compare a number of newly developed methods that enables the direct visualization of specific, endogenous DNA sequences in living cells, especially that utilizing the CRISPR-Cas9 system. We further discuss the practical considerations in implementing the CRIPSR imaging technique in order to achieve sufficient signal-to-background level, high specificity and high labeling efficiency. With these DNA labeling methods enabling the tracking of the copy number, localization and movement of genomic elements, we discuss their potential applications in understanding the searching and targeting mechanism of Cas9-sgRNA complex, investigating chromosome organization, as well as visualizing genome instability and rearrangement.
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