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10.1111/xen.12236 http://scihub22266oqcxt.onion/10.1111/xen.12236 C5052084!5052084!27188532     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Xenotransplantation 2016 ; 23 (3): 222-36 Nephropedia Template TP {{tp|p=27188532|t=2016. Platelet sequestration and activation during GalTKO hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and VWF |pdf=|usr=}}{{27188532}} gab.com Text Platelet sequestration and activation during GalTKO hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and VWF JO: Xenotransplantation http://www.kidney.de/pget.php?&tw=1&pmid=27188532 #FOAvip Background: Here we ask whether platelet GPIb and GPIIb/IIIa receptors modulate platelet sequestration and activation during GalTKO.hCD46 pig lung xenograft perfusion. Methods: GalTKO.hCD46 transgenic pig lungs were perfused with heparinized fresh human blood. Results from perfusions in which ?GPIb Fab (6B4, 10mg/L blood, n=6), ?GPIIb/IIIa Fab (ReoPro, 3.5mg/L blood, n=6), or both drugs (n=4) were administered to the perfusate were compared to 2 additional groups in which the donor pig received DDAVP, 3?g/kg (to pre-deplete pVWF, the main GPIb ligand), with or without ?GPIb (n=6 each). Results: Platelet sequestration was significantly delayed in ?GPIb, ?GPIb+DDAVP and ?GPIb+?GPIIb/IIIa groups. Median lung ?survival? was significantly longer (>240 vs. 162min reference, p=0.016), and platelet activation (as CD62P and ?TG) were significantly inhibited, when pigs were pre-treated with DDAVP, with or without ?GPIb Fab treatment. Pulmonary vascular resistance rise was not significantly attenuated in any group, and was associated with residual thromboxane and histamine elaboration. Conclusions: The GPIb-VWF and GPIIb/IIIa axes play important roles in platelet sequestration and coagulation cascade activation during GalTKO.hCD46 lung xenograft injury. GPIb blockade significantly reduces platelet activation and delays platelet sequestration in this xenolung rejection model, an effect amplified by adding ?GPIIb/IIIa blockade or depletion of VWF from pig lung. Twit Text FOAVip Platelet sequestration and activation during GalTKO hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and VWF ????Xenotransplantation http://www.kidney.de/pget.php?&tw=1&pmid=27188532 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27188532 #FOAvip English Wikipedia <ref>{{Cite pmid|27188532}}</ref> Platelet sequestration and activation during GalTKO hCD46 pig lung perfusion by human blood is primarily mediated by GPIb, GPIIb/IIIa, and VWF #MMPMID27188532 Burdorf L; Riner A; Rybak E; Salles I; De Meyer S; Shah A; Quinn K; Harris D; Zhang T; Parsell D; Ali F; Schwartz E; Kang E; Cheng X; Sievert E; Zhao Y; Braileanu G; Phelps C; Ayares D; Deckmyn H; Pierson R; Azimzadeh A Xenotransplantation 2016[May]; 23 (3): 222-36 PMID27188532show ga Background: Here we ask whether platelet GPIb and GPIIb/IIIa receptors modulate platelet sequestration and activation during GalTKO.hCD46 pig lung xenograft perfusion. Methods: GalTKO.hCD46 transgenic pig lungs were perfused with heparinized fresh human blood. Results from perfusions in which ?GPIb Fab (6B4, 10mg/L blood, n=6), ?GPIIb/IIIa Fab (ReoPro, 3.5mg/L blood, n=6), or both drugs (n=4) were administered to the perfusate were compared to 2 additional groups in which the donor pig received DDAVP, 3?g/kg (to pre-deplete pVWF, the main GPIb ligand), with or without ?GPIb (n=6 each). Results: Platelet sequestration was significantly delayed in ?GPIb, ?GPIb+DDAVP and ?GPIb+?GPIIb/IIIa groups. Median lung ?survival? was significantly longer (>240 vs. 162min reference, p=0.016), and platelet activation (as CD62P and ?TG) were significantly inhibited, when pigs were pre-treated with DDAVP, with or without ?GPIb Fab treatment. Pulmonary vascular resistance rise was not significantly attenuated in any group, and was associated with residual thromboxane and histamine elaboration. Conclusions: The GPIb-VWF and GPIIb/IIIa axes play important roles in platelet sequestration and coagulation cascade activation during GalTKO.hCD46 lung xenograft injury. GPIb blockade significantly reduces platelet activation and delays platelet sequestration in this xenolung rejection model, an effect amplified by adding ?GPIIb/IIIa blockade or depletion of VWF from pig lung. äPlatelet sequestration and activation during GalTKO hCD46 pig lung per(epmc).pdf DeepDyve Pubget Overpricing