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10.1101/gr.201244.115 http://scihub22266oqcxt.onion/10.1101/gr.201244.115 C5052047!5052047!27225843     free     free     free       Genome+Res 2016 ; 26 (9): 1245-56 Nephropedia Template TP {{tp|p=27225843|t=2016. Chromatin dynamics during DNA replication |pdf=|usr=}}{{27225843}} gab.com Text Chromatin dynamics during DNA replication JO: Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=27225843 #FOAvip Chromatin is composed of DNA and histones, which provide a unified platform for regulating DNA-related processes, mostly through their post-translational modification. During DNA replication, histone arrangement is perturbed, first to allow progression of DNA polymerase and then during repackaging of the replicated DNA. To study how DNA replication influences the pattern of histone modification, we followed the cell-cycle dynamics of 10 histone marks in budding yeast. We find that histones deposited on newly replicated DNA are modified at different rates: While some marks appear immediately upon replication (e.g., H4K16ac, H3K4me1), others increase with transcription-dependent delays (e.g., H3K4me3, H3K36me3). Notably, H3K9ac was deposited as a wave preceding the replication fork by ?5?6 kb. This replication-guided H3K9ac was fully dependent on the acetyltransferase Rtt109, while expression-guided H3K9ac was deposited by Gcn5. Further, topoisomerase depletion intensified H3K9ac in front of the replication fork and in sites where RNA polymerase II was trapped, suggesting supercoiling stresses trigger H3K9 acetylation. Our results assign complementary roles for DNA replication and gene expression in defining the pattern of histone modification. Twit Text FOAVip Chromatin dynamics during DNA replication ????Genome Res http://www.kidney.de/pget.php?&tw=1&pmid=27225843 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27225843 #FOAvip English Wikipedia <ref>{{Cite pmid|27225843}}</ref> Chromatin dynamics during DNA replication #MMPMID27225843 Bar-Ziv R; Voichek Y; Barkai N Genome Res 2016[Sep]; 26 (9): 1245-56 PMID27225843show ga Chromatin is composed of DNA and histones, which provide a unified platform for regulating DNA-related processes, mostly through their post-translational modification. During DNA replication, histone arrangement is perturbed, first to allow progression of DNA polymerase and then during repackaging of the replicated DNA. To study how DNA replication influences the pattern of histone modification, we followed the cell-cycle dynamics of 10 histone marks in budding yeast. We find that histones deposited on newly replicated DNA are modified at different rates: While some marks appear immediately upon replication (e.g., H4K16ac, H3K4me1), others increase with transcription-dependent delays (e.g., H3K4me3, H3K36me3). Notably, H3K9ac was deposited as a wave preceding the replication fork by ?5?6 kb. This replication-guided H3K9ac was fully dependent on the acetyltransferase Rtt109, while expression-guided H3K9ac was deposited by Gcn5. Further, topoisomerase depletion intensified H3K9ac in front of the replication fork and in sites where RNA polymerase II was trapped, suggesting supercoiling stresses trigger H3K9 acetylation. Our results assign complementary roles for DNA replication and gene expression in defining the pattern of histone modification. äChromatin dynamics during DNA replication (epmc).pdf DeepDyve Pubget Overpricing