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10.1016/j.virol.2016.02.007 http://scihub22266oqcxt.onion/10.1016/j.virol.2016.02.007 C5051663!5051663 !26901486     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26901486 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Virology 2016 ; 492 (ä): 66-72 Nephropedia Template TP {{tp|p=26901486 |t=2016. Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells |pdf=|usr=}}{{26901486 }} gab.com Text Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells JO: Virology http://www.kidney.de/pget.php?&tw=1&pmid=26901486 #FOAvip BK polyomavirus (BKPyV) is a human pathogen that causes polyomavirus-associated nephropathy and hemorrhagic cystitis in transplant patients. Gangliosides and caveolin proteins have previously been reported to be required for BKPyV infection in animal cell models. Recent studies from our lab and others, however, have indicated that the identity of the cells used for infection studies can greatly influence the behavior of the virus. We therefore wished to re-examine BKPyV entry in a physiologically relevant primary cell culture model, human renal proximal tubule epithelial cells. Using siRNA knockdowns, we interfered with expression of UDP-glucose ceramide glucosyltransferase (UGCG), and the endocytic vesicle coat proteins caveolin 1, caveolin 2, and clathrin heavy chain. The results demonstrate that while BKPyV does require gangliosides for efficient infection, it can enter its natural host cells via a caveolin- and clathrin-independent pathway. The results emphasize the importance of studying viruses in a relevant cell culture model. Twit Text FOAVip Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells ????Virology http://www.kidney.de/pget.php?&tw=1&pmid=26901486 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26901486 #FOAvip English Wikipedia <ref>{{Cite pmid|26901486 }}</ref> Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells #MMPMID26901486 Zhao L ; Marciano AT ; Rivet CR ; Imperiale MJ Virology 2016[May]; 492 (ä): 66-72 PMID26901486 show ga BK polyomavirus (BKPyV) is a human pathogen that causes polyomavirus-associated nephropathy and hemorrhagic cystitis in transplant patients. Gangliosides and caveolin proteins have previously been reported to be required for BKPyV infection in animal cell models. Recent studies from our lab and others, however, have indicated that the identity of the cells used for infection studies can greatly influence the behavior of the virus. We therefore wished to re-examine BKPyV entry in a physiologically relevant primary cell culture model, human renal proximal tubule epithelial cells. Using siRNA knockdowns, we interfered with expression of UDP-glucose ceramide glucosyltransferase (UGCG), and the endocytic vesicle coat proteins caveolin 1, caveolin 2, and clathrin heavy chain. The results demonstrate that while BKPyV does require gangliosides for efficient infection, it can enter its natural host cells via a caveolin- and clathrin-independent pathway. The results emphasize the importance of studying viruses in a relevant cell culture model. |*Host-Pathogen Interactions [MESH] |BK Virus/*drug effects/genetics/metabolism [MESH] |Caveolin 1/antagonists & inhibitors/*genetics/metabolism [MESH] |Caveolin 2/antagonists & inhibitors/*genetics/metabolism [MESH] |Cell Line [MESH] |Clathrin Heavy Chains/antagonists & inhibitors/*genetics/metabolism [MESH] |Epithelial Cells/*drug effects/virology [MESH] |G(M1) Ganglioside/pharmacology [MESH] |Gangliosides/pharmacology [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Kidney Tubules, Proximal/drug effects/virology [MESH] |MicroRNAs/genetics/metabolism [MESH] |Monosaccharide Transport Proteins/antagonists & inhibitors/genetics/metabolism [MESH] |Primary Cell Culture [MESH] |RNA, Small Interfering/genetics/metabolism [MESH]Caveolin- and clathrin-independent entry of BKPyV into primary human p(epmc).pdf DeepDyve Pubget Overpricing