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10.1002/cbic.201600052

http://scihub22266oqcxt.onion/10.1002/cbic.201600052
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C5051347!5051347!27059426
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suck abstract from ncbi

pmid27059426      Chembiochem 2016 ; 17 (12): 1138-41
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  • DNA Walker-Regulated Cancer Cell Growth Inhibition #MMPMID27059426
  • Li F; Cha TG; Pan J; Ozcelikkale A; Han B; Choi JH
  • Chembiochem 2016[Jun]; 17 (12): 1138-41 PMID27059426show ga
  • We demonstrate a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anti-cancer oligonucleotides are controlled by the walker operation. With the walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in-situ cancer cell growth inhibition.
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