DNA Walker-Regulated Cancer Cell Growth Inhibition #MMPMID27059426
Li F; Cha TG; Pan J; Ozcelikkale A; Han B; Choi JH
Chembiochem 2016[Jun]; 17 (12): 1138-41 PMID27059426show ga
We demonstrate a DNAzyme-based walker system as a controlled oligonucleotide drug AS1411 release platform for breast cancer treatment. AS1411 strands are released from fuel strands as a walker moves along its carbon nanotube track. The release rate and amount of anti-cancer oligonucleotides are controlled by the walker operation. With the walker system embedded within the collagen extracellular matrix, we show that this drug release system can be used for in-situ cancer cell growth inhibition.