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10.1016/j.jdiacomp.2016.05.016 http://scihub22266oqcxt.onion/10.1016/j.jdiacomp.2016.05.016 C5050074!5050074!27267264     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27267264&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Diabetes+Complications 2016 ; 30 (8): 1651-8 Nephropedia Template TP {{tp|p=27267264|t=2016. INTRA-ISLET GLUCAGON-LIKE PEPTIDE 1 |pdf=|usr=}}{{27267264}} gab.com Text INTRA-ISLET GLUCAGON-LIKE PEPTIDE 1 JO: J Diabetes Complications http://www.kidney.de/pget.php?&tw=1&pmid=27267264 #FOAvip Purpose: Glucagon-like peptide-1 (GLP-1) is originally identified in the gut as an incretin hormone, and it is potent in stimulating insulin secretion in the pancreas. However, increasing evidence suggests that GLP-1 is also produced locally within pancreatic islets. This review focuses on the past and current discoveries regarding intra-islet GLP-1 production and its functions. Main findings: There has been a long-standing debate with regard to whether GLP-1 is produced in the pancreatic ? cells. Early controversies lead to the widely accepted conclusion that the vast majority of proglucagon is processed to form glucagon in the pancreas, whereas an insignificant amount is cleaved to produce GLP-1. With technological advancements, recent studies have shown that bioactive GLP-1 is produced locally in the pancreas, and the expression and secretion of GLP-1 within islets are regulated by various factors such as cytokines, hyperglycemia, and ? cell injury. Conclusions: GLP-1 is produced by the pancreatic ? cells, and it is fully functional as an incretin. Therefore, intra-islet GLP-1 may exert insulinotropic and glucagonostatic effects locally via paracrine and/or autocrine actions, under both normal and diabetic conditions. Twit Text FOAVip INTRA-ISLET GLUCAGON-LIKE PEPTIDE 1 ????J Diabetes Complications http://www.kidney.de/pget.php?&tw=1&pmid=27267264 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27267264 #FOAvip English Wikipedia <ref>{{Cite pmid|27267264}}</ref> INTRA-ISLET GLUCAGON-LIKE PEPTIDE 1 #MMPMID27267264 Fava GE; Dong EW; Wu H J Diabetes Complications 2016[Nov]; 30 (8): 1651-8 PMID27267264show ga Purpose: Glucagon-like peptide-1 (GLP-1) is originally identified in the gut as an incretin hormone, and it is potent in stimulating insulin secretion in the pancreas. However, increasing evidence suggests that GLP-1 is also produced locally within pancreatic islets. This review focuses on the past and current discoveries regarding intra-islet GLP-1 production and its functions. Main findings: There has been a long-standing debate with regard to whether GLP-1 is produced in the pancreatic ? cells. Early controversies lead to the widely accepted conclusion that the vast majority of proglucagon is processed to form glucagon in the pancreas, whereas an insignificant amount is cleaved to produce GLP-1. With technological advancements, recent studies have shown that bioactive GLP-1 is produced locally in the pancreas, and the expression and secretion of GLP-1 within islets are regulated by various factors such as cytokines, hyperglycemia, and ? cell injury. Conclusions: GLP-1 is produced by the pancreatic ? cells, and it is fully functional as an incretin. Therefore, intra-islet GLP-1 may exert insulinotropic and glucagonostatic effects locally via paracrine and/or autocrine actions, under both normal and diabetic conditions. äINTRA-ISLET GLUCAGON-LIKE PEPTIDE 1 (epmc).pdf DeepDyve Pubget Overpricing