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10.1242/jcs.195867 http://scihub22266oqcxt.onion/10.1242/jcs.195867 C5047679!5047679!27505898     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Sci 2016 ; 129 (18): 3412-25 Nephropedia Template TP {{tp|p=27505898|t=2016. Persistent nuclear actin filaments inhibit transcription by RNA polymerase II |pdf=|usr=}}{{27505898}} gab.com Text Persistent nuclear actin filaments inhibit transcription by RNA polymerase II JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=27505898 #FOAvip Actin is abundant in the nucleus and it is clear that nuclear actin has important functions. However, mystery surrounds the absence of classical actin filaments in the nucleus. To address this question, we investigated how polymerizing nuclear actin into persistent nuclear actin filaments affected transcription by RNA polymerase II. Nuclear filaments impaired nuclear actin dynamics by polymerizing and sequestering nuclear actin. Polymerizing actin into stable nuclear filaments disrupted the interaction of actin with RNA polymerase II and correlated with impaired RNA polymerase II localization, dynamics, gene recruitment, and reduced global transcription and cell proliferation. Polymerizing and crosslinking nuclear actin in vitro similarly disrupted the actin?RNA-polymerase-II interaction and inhibited transcription. These data rationalize the general absence of stable actin filaments in mammalian somatic nuclei. They also suggest a dynamic pool of nuclear actin is required for the proper localization and activity of RNA polymerase II. Twit Text FOAVip Persistent nuclear actin filaments inhibit transcription by RNA polymerase II ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=27505898 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27505898 #FOAvip English Wikipedia <ref>{{Cite pmid|27505898}}</ref> Persistent nuclear actin filaments inhibit transcription by RNA polymerase II #MMPMID27505898 Serebryannyy LA; Parilla M; Annibale P; Cruz CM; Laster K; Gratton E; Kudryashov D; Kosak ST; Gottardi CJ; de Lanerolle P J Cell Sci 2016[Sep]; 129 (18): 3412-25 PMID27505898show ga Actin is abundant in the nucleus and it is clear that nuclear actin has important functions. However, mystery surrounds the absence of classical actin filaments in the nucleus. To address this question, we investigated how polymerizing nuclear actin into persistent nuclear actin filaments affected transcription by RNA polymerase II. Nuclear filaments impaired nuclear actin dynamics by polymerizing and sequestering nuclear actin. Polymerizing actin into stable nuclear filaments disrupted the interaction of actin with RNA polymerase II and correlated with impaired RNA polymerase II localization, dynamics, gene recruitment, and reduced global transcription and cell proliferation. Polymerizing and crosslinking nuclear actin in vitro similarly disrupted the actin?RNA-polymerase-II interaction and inhibited transcription. These data rationalize the general absence of stable actin filaments in mammalian somatic nuclei. They also suggest a dynamic pool of nuclear actin is required for the proper localization and activity of RNA polymerase II. äPersistent nuclear actin filaments inhibit transcription by RNA polyme(epmc).pdf DeepDyve Pubget Overpricing