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10.1242/jcs.189225 http://scihub22266oqcxt.onion/10.1242/jcs.189225 C5047677!5047677 !27505892     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27505892 &cmd=llinks): Failed to open stream: HTTP request failed! 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Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography |pdf=|usr=}}{{27505892 }} gab.com Text Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=27505892 #FOAvip Sickle cell disease is a destructive genetic disorder characterized by the formation of fibrils of deoxygenated hemoglobin, leading to the red blood cell (RBC) morphology changes that underlie the clinical manifestations of this disease. Using cryogenic soft X-ray tomography (SXT), we characterized the morphology of sickled RBCs in terms of volume and the number of protrusions per cell. We were able to identify statistically a relationship between the number of protrusions and the volume of the cell, which is known to correlate to the severity of sickling. This structural polymorphism allows for the classification of the stages of the sickling process. Recent studies have shown that elevated sphingosine kinase 1 (Sphk1)-mediated sphingosine 1-phosphate production contributes to sickling. Here, we further demonstrate that compound 5C, an inhibitor of Sphk1, has anti-sickling properties. Additionally, the variation in cellular morphology upon treatment suggests that this drug acts to delay the sickling process. SXT is an effective tool that can be used to identify the morphology of the sickling process and assess the effectiveness of potential therapeutics. Twit Text FOAVip Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=27505892 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27505892 #FOAvip English Wikipedia <ref>{{Cite pmid|27505892 }}</ref> Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography #MMPMID27505892 Darrow MC ; Zhang Y ; Cinquin BP ; Smith EA ; Boudreau R ; Rochat RH ; Schmid MF ; Xia Y ; Larabell CA ; Chiu W J Cell Sci 2016[Sep]; 129 (18 ): 3511-7 PMID27505892 show ga Sickle cell disease is a destructive genetic disorder characterized by the formation of fibrils of deoxygenated hemoglobin, leading to the red blood cell (RBC) morphology changes that underlie the clinical manifestations of this disease. Using cryogenic soft X-ray tomography (SXT), we characterized the morphology of sickled RBCs in terms of volume and the number of protrusions per cell. We were able to identify statistically a relationship between the number of protrusions and the volume of the cell, which is known to correlate to the severity of sickling. This structural polymorphism allows for the classification of the stages of the sickling process. Recent studies have shown that elevated sphingosine kinase 1 (Sphk1)-mediated sphingosine 1-phosphate production contributes to sickling. Here, we further demonstrate that compound 5C, an inhibitor of Sphk1, has anti-sickling properties. Additionally, the variation in cellular morphology upon treatment suggests that this drug acts to delay the sickling process. SXT is an effective tool that can be used to identify the morphology of the sickling process and assess the effectiveness of potential therapeutics. |Anemia, Sickle Cell/*enzymology [MESH] |Animals [MESH] |Cell Surface Extensions/drug effects/metabolism [MESH] |Erythrocytes/drug effects/*enzymology [MESH] |Humans [MESH] |Mice [MESH] |Phosphotransferases (Alcohol Group Acceptor)/*metabolism [MESH] |Protein Kinase Inhibitors/pharmacology [MESH]Visualizing red blood cell sickling and the effects of inhibition of s(epmc).pdf DeepDyve Pubget Overpricing