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10.1038/bjc.2016.274 http://scihub22266oqcxt.onion/10.1038/bjc.2016.274 C5046217!5046217!27599041     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Cancer 2016 ; 115 (7): 831-40 Nephropedia Template TP {{tp|p=27599041|t=2016. Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer |pdf=|usr=}}{{27599041}} gab.com Text Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27599041 #FOAvip Background:: Tumour budding is a histological finding in epithelial cancers indicating an unfavourable phenotype. Previous studies have demonstrated that it is a negative prognostic indicator in colorectal cancer (CRC), and has been proposed as an additional factor to incorporate into staging protocols. Methods:: A systematic review of papers until March 2016 published on Embase, Medline, PubMed, PubMed Central and Cochrane databases pertaining to tumour budding in CRC was performed. Study end points were the presence of lymph node metastases, recurrence (local and distal) and 5-year cancer-related death. Results:: A total of 7821 patients from 34 papers were included, with a mean rate of tumour budding of 36.8±16.5%. Pooled analysis suggested that specimens exhibiting tumour budding were significantly associated with lymph node positivity (OR 4.94, 95% CI 3.96?6.17, P<0.00001), more likely to develop disease recurrence over the time period (OR 5.50, 95% CI 3.64?8.29, P<0.00001) and more likely to lead to cancer-related death at 5 years (OR 4.51, 95% CI 2.55?7.99, P<0.00001). Conclusions:: Tumour budding in CRC is strongly predictive of lymph node metastases, recurrence and cancer-related death at 5 years, and its incorporation into the CRC staging algorithm will contribute to more effective risk stratification. Twit Text FOAVip Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27599041 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27599041 #FOAvip English Wikipedia <ref>{{Cite pmid|27599041}}</ref> Systematic review and meta-analysis of the impact of tumour budding in colorectal cancer #MMPMID27599041 Rogers AC; Winter DC; Heeney A; Gibbons D; Lugli A; Puppa G; Sheahan K Br J Cancer 2016[Sep]; 115 (7): 831-40 PMID27599041show ga Background:: Tumour budding is a histological finding in epithelial cancers indicating an unfavourable phenotype. Previous studies have demonstrated that it is a negative prognostic indicator in colorectal cancer (CRC), and has been proposed as an additional factor to incorporate into staging protocols. Methods:: A systematic review of papers until March 2016 published on Embase, Medline, PubMed, PubMed Central and Cochrane databases pertaining to tumour budding in CRC was performed. Study end points were the presence of lymph node metastases, recurrence (local and distal) and 5-year cancer-related death. Results:: A total of 7821 patients from 34 papers were included, with a mean rate of tumour budding of 36.8±16.5%. Pooled analysis suggested that specimens exhibiting tumour budding were significantly associated with lymph node positivity (OR 4.94, 95% CI 3.96?6.17, P<0.00001), more likely to develop disease recurrence over the time period (OR 5.50, 95% CI 3.64?8.29, P<0.00001) and more likely to lead to cancer-related death at 5 years (OR 4.51, 95% CI 2.55?7.99, P<0.00001). Conclusions:: Tumour budding in CRC is strongly predictive of lymph node metastases, recurrence and cancer-related death at 5 years, and its incorporation into the CRC staging algorithm will contribute to more effective risk stratification. äSystematic review and meta-analysis of the impact of tumour budding in(epmc).pdf DeepDyve Pubget Overpricing