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10.1111/imm.12638 http://scihub22266oqcxt.onion/10.1111/imm.12638 C5046053!5046053 !27329564     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27329564 &cmd=llinks): Failed to open stream: HTTP request failed! 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High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation |pdf=|usr=}}{{27329564 }} gab.com Text High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=27329564 #FOAvip Interleukin-1? (IL-1?), a potent pro-inflammatory cytokine, has been implicated in many diseases, including atherosclerosis. Activation of IL-1? is controlled by a multi-protein complex, the inflammasome. The exact initiating event in atherosclerosis is unknown, but recent work has demonstrated that cholesterol crystals (CC) may promote atherosclerosis development by activation of the inflammasome. High-density lipoprotein (HDL) has consistently been shown to be anti-atherogenic and to have anti-inflammatory effects, but its mechanism of action is unclear. We demonstrate here that HDL is able to suppress IL-1? secretion in response to cholesterol crystals in THP-1 cells and in human-monocyte-derived macrophages. HDL is able to blunt inflammatory monocyte cell recruitment in vivo following intraperitoneal CC injection in mice. HDL appears to modulate inflammasome activation in several ways. It reduces the loss of lysosomal membrane integrity following the phagocytosis of CC, but the major mechanism for the suppression of inflammasome activation by HDL is decreased expression of pro-IL-1? and NLRP3, and reducing caspase-1 activation. In summary, we have described a novel anti-inflammatory effect of HDL, namely its ability to suppress inflammasome activation by CC by modulating the expression of several key components of the inflammasome. Twit Text FOAVip High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=27329564 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27329564 #FOAvip English Wikipedia <ref>{{Cite pmid|27329564 }}</ref> High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation #MMPMID27329564 Thacker SG ; Zarzour A ; Chen Y ; Alcicek MS ; Freeman LA ; Sviridov DO ; Demosky SJ Jr ; Remaley AT Immunology 2016[Nov]; 149 (3 ): 306-319 PMID27329564 show ga Interleukin-1? (IL-1?), a potent pro-inflammatory cytokine, has been implicated in many diseases, including atherosclerosis. Activation of IL-1? is controlled by a multi-protein complex, the inflammasome. The exact initiating event in atherosclerosis is unknown, but recent work has demonstrated that cholesterol crystals (CC) may promote atherosclerosis development by activation of the inflammasome. High-density lipoprotein (HDL) has consistently been shown to be anti-atherogenic and to have anti-inflammatory effects, but its mechanism of action is unclear. We demonstrate here that HDL is able to suppress IL-1? secretion in response to cholesterol crystals in THP-1 cells and in human-monocyte-derived macrophages. HDL is able to blunt inflammatory monocyte cell recruitment in vivo following intraperitoneal CC injection in mice. HDL appears to modulate inflammasome activation in several ways. It reduces the loss of lysosomal membrane integrity following the phagocytosis of CC, but the major mechanism for the suppression of inflammasome activation by HDL is decreased expression of pro-IL-1? and NLRP3, and reducing caspase-1 activation. In summary, we have described a novel anti-inflammatory effect of HDL, namely its ability to suppress inflammasome activation by CC by modulating the expression of several key components of the inflammasome. |Animals [MESH] |Anti-Inflammatory Agents/*therapeutic use [MESH] |Atherosclerosis/*drug therapy/immunology [MESH] |Cell Line [MESH] |Cholesterol/immunology [MESH] |Female [MESH] |Humans [MESH] |Inflammasomes/*metabolism [MESH] |Inflammation/*drug therapy/immunology [MESH] |Interleukin-1beta/*metabolism [MESH] |Lipoproteins, HDL/*therapeutic use [MESH] |Macrophages/*drug effects/immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH]High-density lipoprotein reduces inflammation from cholesterol crystal(epmc).pdf DeepDyve Pubget Overpricing