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10.1038/ncb3406 http://scihub22266oqcxt.onion/10.1038/ncb3406 C5045721!5045721!27617929     free     free     free       Nat+Cell+Biol 2016 ; 18 (10): 1054-64 Nephropedia Template TP {{tp|p=27617929|t=2016. Self-repair promotes microtubule rescue |pdf=|usr=}}{{27617929}} gab.com Text Self-repair promotes microtubule rescue JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27617929 #FOAvip The dynamic instability of microtubules is characterised by slow growth phases stochastically interrupted by rapid depolymerisations called catastrophes. Rescue events can arrest the depolymerisation and restore microtubule elongation. However the origin of these rescue events remain unexplained. Here we show that microtubule lattice self-repair, in structurally damaged sites, is responsible for the rescue of microtubule growth. Tubulin photo-conversion in cells revealed that free tubulin dimers can incorporate along the shafts of microtubules, especially in regions where microtubules cross each other, form bundles or become bent due to mechanical constraints. These incorporation sites appeared to act as effective rescue sites ensuring microtubule rejuvenation. By securing damaged microtubule growth, the self-repair process supports a mechanosensitive growth by specifically promoting microtubule assembly in regions where they are subjected to physical constraints. Twit Text FOAVip Self-repair promotes microtubule rescue ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27617929 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27617929 #FOAvip English Wikipedia <ref>{{Cite pmid|27617929}}</ref> Self-repair promotes microtubule rescue #MMPMID27617929 Aumeier C; Schaedel L; Gaillard J; John K; Blanchoin L; Théry M Nat Cell Biol 2016[Oct]; 18 (10): 1054-64 PMID27617929show ga The dynamic instability of microtubules is characterised by slow growth phases stochastically interrupted by rapid depolymerisations called catastrophes. Rescue events can arrest the depolymerisation and restore microtubule elongation. However the origin of these rescue events remain unexplained. Here we show that microtubule lattice self-repair, in structurally damaged sites, is responsible for the rescue of microtubule growth. Tubulin photo-conversion in cells revealed that free tubulin dimers can incorporate along the shafts of microtubules, especially in regions where microtubules cross each other, form bundles or become bent due to mechanical constraints. These incorporation sites appeared to act as effective rescue sites ensuring microtubule rejuvenation. By securing damaged microtubule growth, the self-repair process supports a mechanosensitive growth by specifically promoting microtubule assembly in regions where they are subjected to physical constraints. äSelf-repair promotes microtubule rescue (epmc).pdf DeepDyve Pubget Overpricing