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10.1038/ng.3664 http://scihub22266oqcxt.onion/10.1038/ng.3664 C5045715!5045715!27618451     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Genet 2016 ; 48 (10): 1112-8 Nephropedia Template TP {{tp|p=27618451|t=2016. The rules and impact of nonsense-mediated mRNA decay in human cancers |pdf=|usr=}}{{27618451}} gab.com Text The rules and impact of nonsense-mediated mRNA decay in human cancers JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=27618451 #FOAvip Premature termination codons (PTCs) cause a large proportion of inherited human genetic diseases. PTC-containing transcripts can be degraded by an mRNA surveillance pathway termed nonsense-mediated mRNA decay (NMD). However, the efficiency of NMD varies; it is inefficient when a PTC is located downstream of the last exon junction complex (EJC). We used matched exome and transcriptome data from 9,769 human tumors to systematically elucidate the rules of NMD targeting in human cells. An integrated model incorporating multiple rules beyond the canonical EJC model explains approximately three-quarters of the non-random variance in NMD efficiency across thousands of PTCs. We also show that dosage compensation may mask the effects of NMD. Applying the NMD model identifies signatures of both positive and negative selection on NMD-triggering mutations in human tumors and provides a classification of tumor suppressor genes. Twit Text FOAVip The rules and impact of nonsense-mediated mRNA decay in human cancers ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=27618451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27618451 #FOAvip English Wikipedia <ref>{{Cite pmid|27618451}}</ref> The rules and impact of nonsense-mediated mRNA decay in human cancers #MMPMID27618451 Lindeboom RG; Supek F; Lehner B Nat Genet 2016[Oct]; 48 (10): 1112-8 PMID27618451show ga Premature termination codons (PTCs) cause a large proportion of inherited human genetic diseases. PTC-containing transcripts can be degraded by an mRNA surveillance pathway termed nonsense-mediated mRNA decay (NMD). However, the efficiency of NMD varies; it is inefficient when a PTC is located downstream of the last exon junction complex (EJC). We used matched exome and transcriptome data from 9,769 human tumors to systematically elucidate the rules of NMD targeting in human cells. An integrated model incorporating multiple rules beyond the canonical EJC model explains approximately three-quarters of the non-random variance in NMD efficiency across thousands of PTCs. We also show that dosage compensation may mask the effects of NMD. Applying the NMD model identifies signatures of both positive and negative selection on NMD-triggering mutations in human tumors and provides a classification of tumor suppressor genes. äThe rules and impact of nonsense-mediated mRNA decay in human cancers (epmc).pdf DeepDyve Pubget Overpricing