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10.1038/ni.3445 http://scihub22266oqcxt.onion/10.1038/ni.3445 C5045264!5045264 !27135604     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27135604 &cmd=llinks): Failed to open stream: HTTP request failed! 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Expression profiling of constitutive mast cells reveals a unique identity within the immune system |pdf=|usr=}}{{27135604 }} gab.com Text Expression profiling of constitutive mast cells reveals a unique identity within the immune system JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27135604 #FOAvip Mast cells are evolutionarily ancient sentinel cells. Like basophils, mast cells express the high-affinity receptor for immunoglobulin E (IgE) and have been linked to host defense and diverse immune-system-mediated diseases. To better characterize the function of these cells, we assessed the transcriptional profiles of mast cells isolated from peripheral connective tissues and basophils isolated from spleen and blood. We found that mast cells were transcriptionally distinct, clustering independently from all other profiled cells, and that mast cells demonstrated considerably greater heterogeneity across tissues than previously appreciated. We observed minimal homology between mast cells and basophils, which shared more overlap with other circulating granulocytes than with mast cells. The derivation of mast-cell and basophil transcriptional signatures underscores their differential capacities to detect environmental signals and influence the inflammatory milieu. Twit Text FOAVip Expression profiling of constitutive mast cells reveals a unique identity within the immune system ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27135604 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27135604 #FOAvip English Wikipedia <ref>{{Cite pmid|27135604 }}</ref> Expression profiling of constitutive mast cells reveals a unique identity within the immune system #MMPMID27135604 Dwyer DF ; Barrett NA ; Austen KF Nat Immunol 2016[Jul]; 17 (7 ): 878-87 PMID27135604 show ga Mast cells are evolutionarily ancient sentinel cells. Like basophils, mast cells express the high-affinity receptor for immunoglobulin E (IgE) and have been linked to host defense and diverse immune-system-mediated diseases. To better characterize the function of these cells, we assessed the transcriptional profiles of mast cells isolated from peripheral connective tissues and basophils isolated from spleen and blood. We found that mast cells were transcriptionally distinct, clustering independently from all other profiled cells, and that mast cells demonstrated considerably greater heterogeneity across tissues than previously appreciated. We observed minimal homology between mast cells and basophils, which shared more overlap with other circulating granulocytes than with mast cells. The derivation of mast-cell and basophil transcriptional signatures underscores their differential capacities to detect environmental signals and influence the inflammatory milieu. |Animals [MESH] |Basophils/*physiology [MESH] |Blood Cells/*physiology [MESH] |Cell Separation [MESH] |Cells, Cultured [MESH] |Connective Tissue Cells/*physiology [MESH] |Flow Cytometry [MESH] |Gene Expression Profiling [MESH] |Immunoglobulin E/metabolism [MESH] |Male [MESH] |Mast Cells/*physiology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Spleen/*cytology [MESH]Expression profiling of constitutive mast cells reveals a unique ident(epmc).pdf DeepDyve Pubget Overpricing