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10.1182/blood-2016-06-723007

http://scihub22266oqcxt.onion/10.1182/blood-2016-06-723007
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C5043128!5043128!27516441
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suck abstract from ncbi


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pmid27516441      Blood 2016 ; 128 (13): 1735-44
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  • Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma #MMPMID27516441
  • Weinhold N; Ashby C; Rasche L; Chavan SS; Stein C; Stephens OW; Tytarenko R; Bauer MA; Meissner T; Deshpande S; Patel PH; Buzder T; Molnar G; Peterson EA; van Rhee F; Zangari M; Thanendrarajan S; Schinke C; Tian E; Epstein J; Barlogie B; Davies FE; Heuck CJ; Walker BA; Morgan GJ
  • Blood 2016[Sep]; 128 (13): 1735-44 PMID27516441show ga
  • Hits in driver genes and bi-allelic events affecting tumor suppressors increase apoptosis resistance and proliferation rate?driving relapse.Excessive biallelic inactivation of tumor suppressors in high-risk cases highlights the need for TP53-independent therapeutic approaches.
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