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10.1182/blood-2016-06-723007 http://scihub22266oqcxt.onion/10.1182/blood-2016-06-723007 C5043128!5043128 !27516441     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27516441 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood 2016 ; 128 (13 ): 1735-44 Nephropedia Template TP {{tp|p=27516441 |t=2016. Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma |pdf=|usr=}}{{27516441 }} gab.com Text Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=27516441 #FOAvip To elucidate the mechanisms underlying relapse from chemotherapy in multiple myeloma, we performed a longitudinal study of 33 patients entered into Total Therapy protocols investigating them using gene expression profiling, high-resolution copy number arrays, and whole-exome sequencing. The study illustrates the mechanistic importance of acquired mutations in known myeloma driver genes and the critical nature of biallelic inactivation events affecting tumor suppressor genes, especially TP53, the end result being resistance to apoptosis and increased proliferation rates, which drive relapse by Darwinian-type clonal evolution. The number of copy number aberration changes and biallelic inactivation of tumor suppressor genes was increased in GEP70 high risk, consistent with genomic instability being a key feature of high risk. In conclusion, the study highlights the impact of acquired genetic events, which enhance the evolutionary fitness level of myeloma-propagating cells to survive multiagent chemotherapy and to result in relapse. Twit Text FOAVip Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=27516441 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27516441 #FOAvip English Wikipedia <ref>{{Cite pmid|27516441 }}</ref> Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma #MMPMID27516441 Weinhold N ; Ashby C ; Rasche L ; Chavan SS ; Stein C ; Stephens OW ; Tytarenko R ; Bauer MA ; Meissner T ; Deshpande S ; Patel PH ; Buzder T ; Molnar G ; Peterson EA ; van Rhee F ; Zangari M ; Thanendrarajan S ; Schinke C ; Tian E ; Epstein J ; Barlogie B ; Davies FE ; Heuck CJ ; Walker BA ; Morgan GJ Blood 2016[Sep]; 128 (13 ): 1735-44 PMID27516441 show ga To elucidate the mechanisms underlying relapse from chemotherapy in multiple myeloma, we performed a longitudinal study of 33 patients entered into Total Therapy protocols investigating them using gene expression profiling, high-resolution copy number arrays, and whole-exome sequencing. The study illustrates the mechanistic importance of acquired mutations in known myeloma driver genes and the critical nature of biallelic inactivation events affecting tumor suppressor genes, especially TP53, the end result being resistance to apoptosis and increased proliferation rates, which drive relapse by Darwinian-type clonal evolution. The number of copy number aberration changes and biallelic inactivation of tumor suppressor genes was increased in GEP70 high risk, consistent with genomic instability being a key feature of high risk. In conclusion, the study highlights the impact of acquired genetic events, which enhance the evolutionary fitness level of myeloma-propagating cells to survive multiagent chemotherapy and to result in relapse. |*Clonal Evolution [MESH] |*Genes, Tumor Suppressor [MESH] |*Mutation [MESH] |Adult [MESH] |Aged [MESH] |Cell Proliferation [MESH] |DNA Copy Number Variations [MESH] |Disease Progression [MESH] |Female [MESH] |Gene Expression Profiling [MESH] |Genes, p53 [MESH] |Genes, ras [MESH] |Genomic Instability [MESH] |Humans [MESH] |Longitudinal Studies [MESH] |Male [MESH] |Middle Aged [MESH] |Models, Genetic [MESH] |Multiple Myeloma/*genetics/pathology/therapy [MESH] |Phosphatidylinositol 3-Kinases/genetics [MESH] |Recurrence [MESH] |Risk Factors [MESH] |Stem Cell Transplantation [MESH]Clonal selection and double-hit events involving tumor suppressor gene(epmc).pdf DeepDyve Pubget Overpricing