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2016 ; 128
(ä): 60-74
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Gamma and Ion-Beam Irradiation of DNA: Free Radical Mechanisms, Electron Effects,
and Radiation Chemical Track Structure
#MMPMID27695205
Sevilla MD
; Becker D
; Kumar A
; Adhikary A
Radiat Phys Chem Oxf Engl 1993
2016[Nov]; 128
(ä): 60-74
PMID27695205
show ga
The focus of our laboratory's investigation is to study the direct-type DNA
damage mechanisms resulting from ?-ray and ion-beam radiation-induced free
radical processes in DNA which lead to molecular damage important to cellular
survival. This work compares the results of low LET (?-) and high LET (ion-beam)
radiation to develop a chemical track structure model for ion-beam radiation
damage to DNA. Recent studies on protonation states of cytosine cation radicals
in the N1-substituted cytosine derivatives in their ground state and
5-methylcytosine cation radicals in ground as well as in excited state are
described. Our results exhibit a radical signature of excitations in
5-methylcytosine cation radical. Moreover, our recent theoretical studies
elucidate the role of electron-induced reactions (low energy electrons (LEE),
presolvated electrons (e(pre)(-)), and aqueous (or, solvated) electrons
(e(aq)(-))). Finally DFT calculations of the ionization potentials of various
sugar radicals show the relative reactivity of these species.