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10.1016/j.radphyschem.2016.04.022

http://scihub22266oqcxt.onion/10.1016/j.radphyschem.2016.04.022
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suck abstract from ncbi


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pmid27695205
      Radiat+Phys+Chem+Oxf+Engl+1993 2016 ; 128 (ä): 60-74
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  • Gamma and Ion-Beam Irradiation of DNA: Free Radical Mechanisms, Electron Effects, and Radiation Chemical Track Structure #MMPMID27695205
  • Sevilla MD ; Becker D ; Kumar A ; Adhikary A
  • Radiat Phys Chem Oxf Engl 1993 2016[Nov]; 128 (ä): 60-74 PMID27695205 show ga
  • The focus of our laboratory's investigation is to study the direct-type DNA damage mechanisms resulting from ?-ray and ion-beam radiation-induced free radical processes in DNA which lead to molecular damage important to cellular survival. This work compares the results of low LET (?-) and high LET (ion-beam) radiation to develop a chemical track structure model for ion-beam radiation damage to DNA. Recent studies on protonation states of cytosine cation radicals in the N1-substituted cytosine derivatives in their ground state and 5-methylcytosine cation radicals in ground as well as in excited state are described. Our results exhibit a radical signature of excitations in 5-methylcytosine cation radical. Moreover, our recent theoretical studies elucidate the role of electron-induced reactions (low energy electrons (LEE), presolvated electrons (e(pre)(-)), and aqueous (or, solvated) electrons (e(aq)(-))). Finally DFT calculations of the ionization potentials of various sugar radicals show the relative reactivity of these species.
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