Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.cub.2016.07.020 http://scihub22266oqcxt.onion/10.1016/j.cub.2016.07.020 C5039087!5039087!27568589     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Biol 2016 ; 26 (18): 2527-34 Nephropedia Template TP {{tp|p=27568589|t=2016. Cytology of DNA Replication Reveals Dynamic Plasticity of Large-scale Chromatin Fibers |pdf=|usr=}}{{27568589}} gab.com Text Cytology of DNA Replication Reveals Dynamic Plasticity of Large-scale Chromatin Fibers JO: Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=27568589 #FOAvip In higher eukaryotic interphase nuclei, the 100s-1000s fold linear compaction of chromatin is difficult to reconcile with its function as a template for transcription, replication, and repair. It is challenging to imagine how DNA and RNA polymerases with their associated molecular machinery would move along the DNA template without transient decondensation of observed large-scale chromatin ?chromonema? fibers [1]. Transcription or replication ?factory? models [2] in which polymerases remain fixed while DNA is reeled through are similarly difficult to conceptualize without transient decondensation of these chromonema fibers. Here we show how a dynamic plasticity of chromatin folding within large-scale chromatin fibers allows DNA replication to take place without significant changes in the global large-scale chromatin compaction or shape of these large-scale chromatin fibers. Time-lapse imaging of lac-operator tagged chromosome regions shows no major change in the overall compaction of these chromosome regions during their DNA replication. Improved pulse-chase labeling of endogenous interphase chromosomes yields a model in which global compaction and shape of large Mbp chromatin domains remains largely invariant during DNA replication, with DNA within these domains undergoing significant movements and redistribution as they move into and then out of adjacent replication foci. In contrast to hierarchical folding models, this dynamic plasticity of large-scale chromatin organization explains how localized changes in DNA topology allow DNA replication to take place without an accompanying global unfolding of large-scale chromatin fibers while suggesting a possible mechanism for maintaining epigenetic programming of large-scale chromatin domains throughout DNA replication. Twit Text FOAVip Cytology of DNA Replication Reveals Dynamic Plasticity of Large-scale Chromatin Fibers ????Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=27568589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27568589 #FOAvip English Wikipedia <ref>{{Cite pmid|27568589}}</ref> Cytology of DNA Replication Reveals Dynamic Plasticity of Large-scale Chromatin Fibers #MMPMID27568589 Deng X; Zhironkina OA; Cherepanynets VD; Strelkova OS; Kireev II; Belmont AS Curr Biol 2016[Sep]; 26 (18): 2527-34 PMID27568589show ga In higher eukaryotic interphase nuclei, the 100s-1000s fold linear compaction of chromatin is difficult to reconcile with its function as a template for transcription, replication, and repair. It is challenging to imagine how DNA and RNA polymerases with their associated molecular machinery would move along the DNA template without transient decondensation of observed large-scale chromatin ?chromonema? fibers [1]. Transcription or replication ?factory? models [2] in which polymerases remain fixed while DNA is reeled through are similarly difficult to conceptualize without transient decondensation of these chromonema fibers. Here we show how a dynamic plasticity of chromatin folding within large-scale chromatin fibers allows DNA replication to take place without significant changes in the global large-scale chromatin compaction or shape of these large-scale chromatin fibers. Time-lapse imaging of lac-operator tagged chromosome regions shows no major change in the overall compaction of these chromosome regions during their DNA replication. Improved pulse-chase labeling of endogenous interphase chromosomes yields a model in which global compaction and shape of large Mbp chromatin domains remains largely invariant during DNA replication, with DNA within these domains undergoing significant movements and redistribution as they move into and then out of adjacent replication foci. In contrast to hierarchical folding models, this dynamic plasticity of large-scale chromatin organization explains how localized changes in DNA topology allow DNA replication to take place without an accompanying global unfolding of large-scale chromatin fibers while suggesting a possible mechanism for maintaining epigenetic programming of large-scale chromatin domains throughout DNA replication. äCytology of DNA Replication Reveals Dynamic Plasticity of Large-scale (epmc).pdf DeepDyve Pubget Overpricing