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10.1128/AAC.00377-16 http://scihub22266oqcxt.onion/10.1128/AAC.00377-16 C5038268!5038268 !27401577     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27401577 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Antimicrob+Agents+Chemother 2016 ; 60 (10 ): 5663-72 Nephropedia Template TP {{tp|p=27401577 |t=2016. Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus Biofilms |pdf=|usr=}}{{27401577 }} gab.com Text Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus Biofilms JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=27401577 #FOAvip It is now well established that bacterial infections are often associated with biofilm phenotypes that demonstrate increased resistance to common antimicrobials. Further, due to the collective attrition of new antibiotic development programs by the pharmaceutical industries, drug repurposing is an attractive alternative. In this work, we screened 1,280 existing commercially available drugs in the Prestwick Chemical Library, some with previously unknown antimicrobial activity, against Staphylococcus aureus, one of the commonly encountered causative pathogens of burn and wound infections. From the primary screen of the entire Prestwick Chemical Library at a fixed concentration of 10 ?M, 104 drugs were found to be effective against planktonic S. aureus strains, and not surprisingly, these were mostly antimicrobials and antiseptics. The activity of 18 selected repurposing candidates, that is, drugs that show antimicrobial activity that are not already considered antimicrobials, observed in the primary screen was confirmed in dose-response experiments. Finally, a subset of nine of these drug candidates was tested against preformed biofilms of S. aureus We found that three of these drugs, niclosamide, carmofur, and auranofin, possessed antimicrobial activity against preformed biofilms, making them attractive candidates for repurposing as novel antibiofilm therapies. Twit Text FOAVip Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus Biofilms ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=27401577 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27401577 #FOAvip English Wikipedia <ref>{{Cite pmid|27401577 }}</ref> Screening a Commercial Library of Pharmacologically Active Small Molecules against Staphylococcus aureus Biofilms #MMPMID27401577 Torres NS ; Abercrombie JJ ; Srinivasan A ; Lopez-Ribot JL ; Ramasubramanian AK ; Leung KP Antimicrob Agents Chemother 2016[Oct]; 60 (10 ): 5663-72 PMID27401577 show ga It is now well established that bacterial infections are often associated with biofilm phenotypes that demonstrate increased resistance to common antimicrobials. Further, due to the collective attrition of new antibiotic development programs by the pharmaceutical industries, drug repurposing is an attractive alternative. In this work, we screened 1,280 existing commercially available drugs in the Prestwick Chemical Library, some with previously unknown antimicrobial activity, against Staphylococcus aureus, one of the commonly encountered causative pathogens of burn and wound infections. From the primary screen of the entire Prestwick Chemical Library at a fixed concentration of 10 ?M, 104 drugs were found to be effective against planktonic S. aureus strains, and not surprisingly, these were mostly antimicrobials and antiseptics. The activity of 18 selected repurposing candidates, that is, drugs that show antimicrobial activity that are not already considered antimicrobials, observed in the primary screen was confirmed in dose-response experiments. Finally, a subset of nine of these drug candidates was tested against preformed biofilms of S. aureus We found that three of these drugs, niclosamide, carmofur, and auranofin, possessed antimicrobial activity against preformed biofilms, making them attractive candidates for repurposing as novel antibiofilm therapies. |Anti-Bacterial Agents/*pharmacology [MESH] |Auranofin/pharmacology [MESH] |Biofilms/drug effects [MESH] |Dose-Response Relationship, Drug [MESH] |Drug Evaluation, Preclinical/methods [MESH] |Drug Repositioning [MESH] |Fluorouracil/analogs & derivatives/pharmacology [MESH] |High-Throughput Screening Assays [MESH] |Methicillin-Resistant Staphylococcus aureus/drug effects [MESH] |Microbial Sensitivity Tests [MESH] |Niclosamide/pharmacology [MESH] |Small Molecule Libraries/*pharmacology [MESH]Screening a Commercial Library of Pharmacologically Active Small Molec(epmc).pdf DeepDyve Pubget Overpricing