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10.3390/ijms17091438 http://scihub22266oqcxt.onion/10.3390/ijms17091438 C5037717!5037717!27589732     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2016 ; 17 (9): ä Nephropedia Template TP {{tp|p=27589732|t=2016. PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation |pdf=|usr=}}{{27589732}} gab.com Text PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27589732 #FOAvip In pigment cells, melanin synthesis takes place in specialized organelles, called melanosomes. The biogenesis and maturation of melanosomes is initiated by an unpigmented step that takes place prior to the initiation of melanin synthesis and leads to the formation of luminal fibrils deriving from the pigment cell-specific pre-melanosomal protein (PMEL). In the lumen of melanosomes, PMEL fibrils optimize sequestration and condensation of the pigment melanin. Interestingly, PMEL fibrils have been described to adopt a typical amyloid-like structure. In contrast to pathological amyloids often associated with neurodegenerative diseases, PMEL fibrils represent an emergent category of physiological amyloids due to their beneficial cellular functions. The formation of PMEL fibrils within melanosomes is tightly regulated by diverse mechanisms, such as PMEL traffic, cleavage and sorting. These mechanisms revealed increasing analogies between the formation of physiological PMEL fibrils and pathological amyloid fibrils. In this review we summarize the known mechanisms of PMEL fibrillation and discuss how the recent understanding of physiological PMEL amyloid formation may help to shed light on processes involved in pathological amyloid formation. Twit Text FOAVip PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27589732 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27589732 #FOAvip English Wikipedia <ref>{{Cite pmid|27589732}}</ref> PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation #MMPMID27589732 Bissig C; Rochin L; van Niel G Int J Mol Sci 2016[Sep]; 17 (9): ä PMID27589732show ga In pigment cells, melanin synthesis takes place in specialized organelles, called melanosomes. The biogenesis and maturation of melanosomes is initiated by an unpigmented step that takes place prior to the initiation of melanin synthesis and leads to the formation of luminal fibrils deriving from the pigment cell-specific pre-melanosomal protein (PMEL). In the lumen of melanosomes, PMEL fibrils optimize sequestration and condensation of the pigment melanin. Interestingly, PMEL fibrils have been described to adopt a typical amyloid-like structure. In contrast to pathological amyloids often associated with neurodegenerative diseases, PMEL fibrils represent an emergent category of physiological amyloids due to their beneficial cellular functions. The formation of PMEL fibrils within melanosomes is tightly regulated by diverse mechanisms, such as PMEL traffic, cleavage and sorting. These mechanisms revealed increasing analogies between the formation of physiological PMEL fibrils and pathological amyloid fibrils. In this review we summarize the known mechanisms of PMEL fibrillation and discuss how the recent understanding of physiological PMEL amyloid formation may help to shed light on processes involved in pathological amyloid formation. äPMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation (epmc).pdf DeepDyve Pubget Overpricing