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10.1093/ckj/sfw048

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suck abstract from ncbi


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pmid27679711      Clin+Kidney+J 2016 ; 9 (5): 661-4
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  • Frequently relapsing anti-glomerular basement membrane antibody disease with changing clinical phenotype and antibody characteristics over time #MMPMID27679711
  • Gu B; Magil AB; Barbour SJ
  • Clin Kidney J 2016[Oct]; 9 (5): 661-4 PMID27679711show ga
  • Anti-glomerular basement membrane (GBM) antibody disease is a typically monophasic autoimmune disease with severe pulmonary and renal involvement. We report an atypical case of frequently relapsing anti-GBM antibody disease with both anti-GBM antibody?positive flares with pulmonary and renal involvement, and anti-GBM antibody?negative flares that were pulmonary limited with no histologic renal disease. This is the first report of alternating disease phenotype and anti-GBM antibody status over time. Disease severity paralleled the detection of anti-GBM antibodies but was independent of IgG subtype staining along the GBM. This case suggests a role for changing subpopulations of pathogenic antibodies as an explanation for variation in disease phenotype and anti-GBM antibody results.
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